Spinal cord tumors
Tumors of the spinal canal are divided into primary and secondary (metastases). These tumors can be located above (extradural or epidural) and under the dura mater of the spinal cord (intradural). Subshell (intradural) tumors can be located outside and inside the spinal cord parenchyma (intramedullary, extramedullary).
Extradural spinal cord tumors
In clinical practice, a neurologist or neurosurgeon is more likely to have extradural spinal cord tumors. Extradural spinal cord tumors are metastases of tumors of organs located near the spine. Metastases from the prostate and mammary glands and lungs, as well as lymphomas and plasmocytic dyscrasias are especially common. The development of metastatic epidural compression of the spinal cord is described in almost all forms of human malignant tumors. The first symptom of epidural (extradural) spinal cord compression is usually a patient's complaint of local back pain. Back pain can increase in the supine position and force the patient to wake up because of it at night. Back pain is often accompanied by radiating root pain, which increases when coughing, sneezing or straining. Often, back pain and local pain on palpation for many weeks precede other symptoms of epidural (extradural) compression of the spinal cord.
Neurological symptoms in a patient with epidural (extradural) compression of the spinal cord usually develop within a few days or weeks. The first manifestation of spinal cord compression syndrome is a progressive weakness in the extremities. Weakness in the extremities can eventually carry all the signs of transverse myelopathy with paraparesis and a level of sensitivity disorders.
With conventional radiography of the spine, you can detect the destruction or compression fracture of the vertebral body at the level corresponding to the spinal cord injury syndrome. Bone scintigraphy is even more informative. Spinal cord compression is most significant when examining the spinal cord on CT, MRI, and myelography (with contrast). The area of horizontal symmetrical expansion and compression of the spinal cord, compressed by an extramedullary pathological formation, is noticeable along the boundaries of the blockade of the subarachnoid space (CSF block). With the cerebrospinal fluid block, the patient also reveals changes from the neighboring vertebrae.
Therapeutic tactics for extramedullary compression of the spinal cord by a tumor can be conservative and operative. In a neurosurgical hospital, a patient with extramedullary compression of the spinal cord by a tumor may undergo laminectomy. The essence of the laminectomy operation is to expand the bone window in the area of compression of the spinal cord by tumor masses. In the conservative method of treatment of patients with extramedullary compression of the spinal cord, large doses of corticosteroids are used in combination with fractional radiation therapy. The outcome of this treatment method will depend on the type of tumor and its sensitivity to radiation therapy. After the introduction of corticosteroids for two days, the severity of leg muscle weakness (paraparesis) in patients often decreases. In some incomplete early syndromes of transverse spinal cord injury, neurosurgical treatment may be appropriate. In any case, individual analysis of treatment tactics is required, taking into account the radiosensitivity of the tumor, the localization of other metastases, and the general condition of the patient. Regardless of the chosen treatment tactics (surgical treatment, radiation therapy), they should be applied to the patient quickly. If a spinal cord compression (spinal compression) is suspected, the patient is prescribed corticosteroids.
When cancer spreads to the spine and presses on the spinal cord, surgery can help restore nerve function. But if the surgery is done late or involves the thoracic part of the spine, the chances of nerve recovery are lower. Also, patients who have more nerve damage before surgery are less likely to walk again after surgery. To improve nerve function, quality of life and survival, it is important to find and treat spinal cord compression early.
Intradural extramedullary spinal cord tumors
Intradural extramedullary spinal cord tumors are inferior to extradural tumors in terms of growth rate. Intradural extramedullary tumors are much less likely to compress the spinal cord. Among intradural extramedullary spinal cord tumors, meningiomas and neurofibromas are more common. Spinal cord tumors such as hemangiopericytoma or other shell tumors in clinical practice are rare in patients.
At the beginning of the lesion of the spinal cord with an intradural extramedullary tumor, patients develop radicular sensitivity disorders and a syndrome of asymmetric neurological disorders. Computed tomography of the spinal cord (CT) and myelography reveal a typical pattern of displacement (dislocation) of the spinal cord away from the tumor located in the subarachnoid space of the spinal cord.
A slight increase in the protein content in the cerebrospinal fluid (CSF) is detected in patients with oncological compression myelopathies of all types. In the case of the formation of the cerebrospinal fluid block of the subarachnoid space of the spinal cord, the protein concentration in CSF increases to 1000-10000 mg/l. This is due to the delay of cerebrospinal fluid dynamics from the caudal sac to the subarachnoid space of the cranial cavity, where its reverse physiological absorption occurs (resorption of cerebrospinal fluid).
In normal adult CSF, there are practically no cellular elements. Their amount in the cerebrospinal fluid in intradural extramedullary tumors of the spinal cord will be small or zero. It should be borne in mind that cytological examination of CSF does not reveal tumor cells. The glucose content in the patient's CSF may also be within the normal range if the tumor is not accompanied by widespread carcinomatous meningitis of the spinal cord membranes.
Epidural abscess of the spinal cord
Treatment of epidural abscess of the spinal cord in patients does not cause difficulties. It is important to diagnose an epidural abscess in time at the beginning of the disease, without confusing it with a tumor lesion of the spinal cord. The following diseases predispose to the occurrence of an epidural abscess of the spinal cord:
- furunculosis of the occipital region of the scalp
- bacteremia (sepsis)
- minor back injuries
Epidural abscess of the spinal cord can develop as a complication after surgery on the structures of the spine (with herniated discs, vertebroplasty, etc.) or lumbar puncture. The cause of the formation of an epidural abscess, which, as it increases in size, squeezes the spinal cord, is osteomyelitis of the spine. The focus of osteomyelitis of the spine may be small and not be detected on conventional radiographs. For an accurate diagnosis of osteomyelitis in a patient, it is necessary to conduct a multi-spiral computed tomography of the spine (MSCT).
With an epidural abscess of the spinal cord in a patient for several days or weeks, it is noted:
- temperature rise of unclear nature
- mild back pain
- local pain on palpation
- nevral root pain (appears later)
Increasing in size, the epidural abscess compresses the spinal cord. This increasing extramedullary compression of the spinal cord causes a neurological syndrome of its transverse lesion, sometimes with a complete break. In the case of an increase in the clinic of compression of the spinal cord with an epidural abscess, its urgent decompression is necessary through laminectomy and drainage of the abscess cavity. In the postoperative period, a patient with an epidural abscess of the spinal cord should be prescribed antibiotics selected based on the sensitivity of the bacterial culture. As with any infectious process, incomplete drainage of the abscess cavity often leads to the development of a chronic granulomatous and fibrous process. The use of antibiotics in this case will not eliminate the patient's compressive effect on the spinal cord. Compression of the spinal cord leaky abscesses in tuberculosis at the moment in developed countries is rare.
Spinal epidural hemorrhage and hematomyelia
In the case of hemorrhage in the spinal cord (hematomyelia) in the subarachnoid and epidural space, the patient may develop a clinical picture of acute transverse myelopathy in a few minutes or hours. Hemorrhages in the spinal cord (hematomyelia) are accompanied by severe back pain. The source of hemorrhage in hematomyelia can be:
- arteriovenous malformation (AVM, angioma, hemangioma) of the spinal cord
- hemorrhage in the tumor
- anticoagulant therapy with warfarin for thrombosis of the venous sinuses of the brain
- spontaneous hemorrhage in the spinal cord (occurs in patients most often)
Epidural hemorrhages of the spinal cord can develop as a result of:
- minor spinal injuries
- lumbar puncture
- anticoagulant therapy with warfarin
- secondarily against the background of blood diseases
Patients' complaints of back pain and root pain in spinal cord hemorrhages (hematomyelia) often precede the onset of weakness by several minutes or hours. Weakness and pain can be significantly pronounced, forcing patients to assume ontological positions when moving. Epidural hematoma at the level of the lumbar segments of the spinal cord is accompanied by the loss of knee and Achilles reflexes, whereas in retroperitoneal hematomas, only knee reflexes usually fall out.
When diagnosing a spinal hemorrhage in a patient, a volumetric process is determined on myelography. Computed tomography of the spine (CT) sometimes does not detect this hematoma, because the blood clot cannot be distinguished from the adjacent bone tissue.
Spinal cord hematomas can form as a result of spontaneous bleeding. Blood clots can be caused by the same factors as epidural hemorrhages, giving a particularly pronounced pain syndrome in the subdural and subarachnoid spaces. In an epidural hemorrhage, the cerebrospinal fluid (CSF) is usually clear or contains a small number of red blood cells. In subarachnoid hemorrhage, the cerebrospinal fluid is initially bloody, and later acquires a pronounced yellow-brown hue (xanthochromia) due to the presence of blood pigments in it. In addition, pleocytosis and a decrease in glucose concentration can be detected in the cerebrospinal fluid. This creates a false picture, similar to bacterial meningitis.
Intraspinal (intramedullary) hematoma can be caused by spontaneous rupture of an internal vascular malformation, such as telangiectasia in the gray matter. More often, it is the result of an injury. If the bleeding begins in the central area, it usually spreads up and down along the axis of the spinal cord into several segments and is referred to as hematomyelia. Clinically, an acute syndrome develops, which can very much resemble the chronic syndrome characteristic of syringomyelia.
Spinal epidural bleeding is rare. It is usually caused not by trauma, but by a rupture of a vascular malformation, most often a small-vascular hemangioma (AVM, angioma) in the epidural space or near it in the bones of the spine. Radiography reveals vertical trabeculae in the spongy substance of the spine bone, characteristic of angioma. Blood is not always collected in the area of the angioma. A hematoma usually develops over the dorsal part of the mid-thoracic spinal cord. It can cause acute root pain at the level of bleeding. Then the syndrome of transverse myelopathy develops with paresthesias, followed by sensitive prolapses. Motor paresis begins in the fingers and feet and rises to the level of spinal cord compression. In such cases, immediate consultation with a neurosurgeon is indicated.
Acute herniated (extrused) disc
Herniation (extrusion) of the intervertebral discs in the lumbar and cervical spine is a fairly common pathology in modern humans. Extrusion of the intervertebral discs of the thoracic spine is less likely to cause compression (compression of the spinal cord). Usually, herniated discs, which can cause compression of the spinal cord and myelopathy, develop at the thoracic level after a spinal injury.
Destruction of the cervical intervertebral discs (extrusion, herniation) with concomitant osteoarthritis of the intervertebral joints and hypertrophy of the posterior longitudinal and yellow ligament (cervical spondylosis) causes chronic myelopathy at the cervical level of the spinal cord in elderly patients.
Other atypical compression lesions of the spinal cord
In patients with long-term treatment of various diseases with the help of hormones of the adrenal cortex (glucocorticoids) or primary Cushing's syndrome, there is a tendency to increased the growth of epidural adipose tissue. Such an increase in the volume of epidural adipose tissue can compress the patient's thoracic spinal cord. In some blood diseases, compression of the spinal cord is caused by foci of extramedullary hemorrhage.
Rare diseases that lead to compression of the spinal cord in patients include:
- eroding aortic aneurysms
- echinococcal and other parasitic cysts
- tuberculosis gummies
- lymphomatous-granulomatous processes
Inflammatory diseases of the intervertebral joints manifest themselves in two clinical forms:
- compression of the lumbar spinal cord or ponytail as a result of ankylosing spondylitis (ankylosing spondylitis).)
- compression of the cervical segments of the spinal cord in the destruction of the cervical apophyseal or atlanto axial joints in rheumatoid arthritis
Complications from joint damage in rheumatoid arthritis that cause effects on the spinal cord are often overlooked by doctors. Anterior subluxation of the bodies of the cervical vertebrae or atlas relative to the second cervical vertebra (C2) can lead to significant damage to the spinal cord up to a fatal outcome in the case of compression after a small injury (whiplash injury of the neck, cervical-occipital syndrome). In a milder case, the patient may develop chronic compression myelopathy, similar to that of cervical spondylosis. The separation of the dentate process from C2 can cause narrowing (stenosis) of the upper part of the spinal canal with compression of the connection of the medulla oblongata and spinal cord, especially in the position of bending the neck with the head tilted forward.