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Neuralgia (intercostal, occipital, facial, glossopharyngeal, trigeminal, metatarsal)

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Understanding Neuralgia (Nerve Pain)

Neuralgia is defined as a painful sensation experienced along the course of a nerve or within the area of its sensory representation on the body (dermatome or cutaneous distribution). It typically involves irritation or damage primarily to the sensory portions of mixed nerves (which carry both sensory and motor fibers) or to sensory nerves themselves. Sympathetic components of the autonomic nervous system can also be involved, contributing to the pain experience.

 

Definition and Affected Structures

Neuralgic pain is often described as sharp, shooting, stabbing, burning, or electric shock-like. It can be intermittent or constant, and may be triggered by non-painful stimuli (allodynia) or be unusually severe in response to painful stimuli (hyperalgesia).

 

General Causes and Classifications by Origin

Neuralgia can arise from a variety of underlying causes and may be classified by its origin:

  • Psychogenic Neuralgia: Pain that is primarily driven or significantly exacerbated by psychological factors (e.g., stress, anxiety, depression), though this is a complex area and often coexists with organic pathology.
  • Occupational Neuralgia: Related to repetitive strain, awkward postures, or specific occupational exposures.
  • Infectious Neuralgia: Caused by viral or bacterial infections directly affecting nerves (e.g., postherpetic neuralgia after shingles, Lyme disease).
  • Traumatic Neuralgia: Resulting from direct injury to a nerve (e.g., contusion, laceration, stretch, compression from fractures or dislocations).
  • Metabolic Neuralgia: Associated with systemic metabolic disorders (e.g., diabetic neuropathy, uremic neuropathy, vitamin deficiencies).
  • Nocturnal Neuralgia: Pain that predominantly occurs or worsens at night (e.g., some forms of carpal tunnel syndrome).
  • Compressive Neuralgia: Due to mechanical compression of a nerve by adjacent structures (e.g., herniated disc, tumors, entrapment within anatomical tunnels).
Diagram illustrating the dermatomes, representing areas of segmental sensory innervation on the surface of the human body. Neuralgic pain often follows these dermatomal patterns.

Classification by Localization (Common Types)

Neuralgia is also distinguished by its anatomical localization (the specific nerve or region affected). Common types include:

  • Occipital Neuralgia: Pain in the distribution of the greater, lesser, or third occipital nerves, typically at the back of the head, often radiating to the scalp.
  • Facial Neuralgia: A broader term for facial pain; trigeminal neuralgia is the most prominent type.
  • Glossopharyngeal Neuralgia: Severe, paroxysmal pain in the throat, tongue base, ear, and tonsillar area, often triggered by swallowing, talking, or coughing.
  • Trigeminal Neuralgia (Tic Douloureux): Characterized by excruciating, brief, electric shock-like pains in the distribution of one or more branches of the trigeminal nerve (CN V) on the face. This is one of the most common and severe neuralgias encountered in clinical practice.
  • Tympanic Plexus Neuralgia (Jacobson's Neuralgia): Otalgia (ear pain) related to irritation of the tympanic plexus.
  • Intercostal Neuralgia: Pain along the course of an intercostal nerve, in the chest wall or upper abdomen.
  • Metatarsal Neuralgia (Metatarsalgia): Pain in the forefoot, particularly in the region of the metatarsal heads. Morton's neuroma is a specific type.
  • Calcaneal Neuralgia (Thalalgia/Talalgia): Pain in the heel region.
  • Causalgia (Complex Regional Pain Syndrome Type II): Severe, persistent burning pain, allodynia, and autonomic dysfunction following a traumatic nerve injury.
  • Repercussion Neuralgia (with Ganglionitis): Pain associated with inflammation of a nerve ganglion (e.g., geniculate ganglionitis in Ramsay Hunt syndrome).

While trigeminal neuralgia is frequently encountered, neuralgias of other localizations are generally much less common in patients.

 

Sciatic Nerve Neuralgia (Sciatica) - An Example

Sciatic nerve neuralgia (commonly known as sciatica) can be a result of various causes, including post-injection neuritis (a form of traumatic neuritis). In such cases, an improperly administered intramuscular injection into the gluteal muscle can lead to the needle and/or the injected drug entering the substance of the sciatic nerve. This causes direct injury to its myelin sheaths and the conductive nerve fibers (axons), resulting in post-injection sciatic nerve neuritis.

Following such injury or other forms of trauma or compression (e.g., by a herniated disc), a scar and adhesions can form within or around the sheaths of the sciatic nerve. This can cause ongoing compression and irritation of the nerve, leading to the onset of characteristic sciatic pain along its distribution (radiating from the buttock down the posterior aspect of the leg, potentially extending to the foot).

Specific Types of Neuralgia

Intercostal Neuralgia

Intercostal neuralgia refers to pain localized along the distribution of one or more intercostal nerves, which run between the ribs. A common cause is damage to the nerve sheath by the herpes zoster virus (shingles), leading to **postherpetic neuralgia (herpetic neuritis)**. This condition is characterized by:

  • Pain: Often described as burning, sharp, stabbing, or aching, following the course of the affected intercostal space(s). The pain can be constant or intermittent and may be severe.
  • Characteristic Rash (in acute herpes zoster): A vesicular (blistering) rash typically appears in a dermatomal distribution corresponding to the affected nerve(s) prior to or concurrently with the onset of pain. Painful vesicles appear on the skin over the projection of the intercostal nerves.
  • Sensory Changes: Allodynia (pain from non-painful stimuli) and hyperalgesia (increased sensitivity to pain) are common in the affected dermatome.

The pain in intercostal neuralgia associated with herpes zoster is caused by inflammation and damage to the intercostal nerve and its ganglion due to viral reactivation within the nerve. Other causes of intercostal neuralgia include direct trauma (e.g., rib fractures), surgical incisions, nerve compression from tumors or other masses, and inflammatory conditions.

With intercostal neuralgia resulting from herpes zoster (shingles), characteristic painful vesicles (blisters) appear on the skin along the projection of the affected intercostal nerves.

 

Trigeminal Neuralgia

Trigeminal neuralgia (TN), also known as tic douloureux, is a chronic pain condition characterized by recurrent episodes of severe, stabbing, electric shock-like pain in the distribution of one or more branches of the trigeminal nerve (CN V) on the face. The trigeminal nerve supplies sensation to the face and motor function to the muscles of mastication.

The pain typically affects one side of the face and can involve areas such as the cheek, jaw, teeth, gums, lips, or less commonly, the eye and forehead. Pain attacks are often triggered by innocuous stimuli like light touch, chewing, talking, brushing teeth, or a cool breeze. Between attacks, patients are usually pain-free. Classical TN is often caused by vascular compression of the trigeminal nerve root by an aberrant artery or vein near the brainstem. Secondary TN can result from tumors, multiple sclerosis, or other lesions affecting the nerve.

Diagram illustrating the common locations of pain on the face experienced during episodes of trigeminal neuralgia, corresponding to the sensory distribution of its branches (ophthalmic, maxillary, mandibular).

 

Occipital Neuralgia

Occipital neuralgia involves chronic pain, often throbbing or piercing, in the distribution of the greater, lesser, or third occipital nerves. The pain typically starts at the base of the skull (occiput) and can radiate over the scalp to the top of the head, and sometimes towards the forehead or behind the eye. The scalp in the affected area is often tender to touch. Causes include trauma (e.g., whiplash), nerve compression by tight neck muscles or arthritic changes in the cervical spine, inflammation, or tumors.

 

Glossopharyngeal Neuralgia

Glossopharyngeal neuralgia (GPN) is a rare condition characterized by severe, paroxysmal (sudden, brief attacks) pain in the sensory distribution of the glossopharyngeal nerve (CN IX). The pain is typically felt in the throat, tonsillar fossa, base of the tongue, or deep in the ear. Attacks can be triggered by swallowing, chewing, talking, coughing, or yawning. Similar to trigeminal neuralgia, GPN pain is often described as sharp, stabbing, or electric shock-like. In some cases, it can be associated with bradycardia, hypotension, or syncope due to vagal nerve involvement.

 

Other Neuralgias

Other specific neuralgias include, but are not limited to:

  • Facial Neuralgia (Atypical): Persistent facial pain that does not fit the classic criteria for trigeminal neuralgia, often described as constant, burning, or aching.
  • Metatarsal Neuralgia (Metatarsalgia): Pain in the forefoot, specifically around the heads of the metatarsal bones. Morton's neuroma is a common cause, involving thickening of the tissue around an interdigital nerve, usually between the third and fourth toes.
  • Pudendal Neuralgia: Pain in the distribution of the pudendal nerve (perineum, genitals, rectal area).

 

Diagnosis of Neuralgia

The diagnosis of neuralgia typically does not cause significant difficulties for experienced specialists, particularly neurologists or pain management physicians. The diagnostic process usually begins with a comprehensive neurological examination of a patient presenting with complaints typical for the suspected type of neuralgia.

 

Clinical Evaluation

  • Detailed Medical History: Onset, location, character, duration, frequency, triggers, and relieving factors of the pain. Associated symptoms, past medical history (trauma, infections, systemic diseases), and medication use.
  • Neurological Examination: To assess sensory function (light touch, pinprick, temperature) in the affected nerve distribution, motor function (if a mixed nerve is involved), reflexes, and to look for specific trigger points or tenderness along the nerve course.

 

Instrumental Diagnostics

In some cases, additional instrumental examinations may be required, particularly if the cause of neuralgia is suspected to be traumatic, compressive, or related to underlying structural pathology:

  • Electroneurography (ENG/NCS) and Electromyography (EMG): These tests evaluate nerve conduction and muscle electrical activity. They can help confirm nerve damage, localize the site of injury or compression, assess severity, and differentiate neuralgia from other neuropathic conditions or myopathies. Particularly useful if neuralgia was preceded by trauma in the projection of the nerve.
  • Imaging Studies:
    • Magnetic Resonance Imaging (MRI): May be necessary to visualize the spine (e.g., MRI of the cervical or lumbosacral spine) or specific nerve plexuses if a compressive lesion like a herniated or protruding intervertebral disc, soft tissue tumor, or vascular malformation is suspected of causing nerve irritation or compression (e.g., in sciatic nerve neuralgia). High-resolution MRI with specific sequences can sometimes visualize vascular compression of cranial nerves (e.g., in trigeminal neuralgia).
    • CT Scan: Useful for evaluating bony abnormalities that might contribute to nerve compression.
    • Ultrasound: High-resolution musculoskeletal ultrasound can sometimes visualize peripheral nerves and identify sites of entrapment or compression.
  • Quantitative Sensory Testing (QST): Can provide more objective measures of sensory thresholds for different modalities.
  • Diagnostic Nerve Blocks: Injecting local anesthetic around the suspected nerve or ganglion can help confirm the source of pain if it provides significant temporary relief.

Evaluation of nerve function using electroneurography (ENG/NCS) is an important component in the diagnosis of various neuralgias, helping to assess nerve integrity and localize potential damage.

MRI examination of the lumbosacral spine is frequently performed in cases of sciatic nerve neuralgia to identify potential causes like herniated intervertebral discs or spinal stenosis compressing nerve roots.

 

Treatment of Neuralgia

The treatment for neuralgia is selected individually for each case, depending on the specific type of neuralgia, its underlying cause, severity of pain, and the patient's overall health. A multimodal approach is often most effective. Treatment generally includes a set of conservative procedures, and in refractory cases, interventional or surgical options may be considered.

 

General Principles and Conservative Management

  • Addressing the Underlying Cause: If a specific cause is identified (e.g., infection, tumor, compression, metabolic disorder), treating that primary condition is paramount.
  • Lifestyle Modifications: Avoiding known trigger factors, ergonomic adjustments for occupational neuralgias.
  • Physical Therapy: Exercises, stretching, posture correction, and modalities like heat/cold therapy can be beneficial for certain types of neuralgia, particularly those with a musculoskeletal component (e.g., some occipital or intercostal neuralgias).

 

Pharmacological Treatment

Medications are a mainstay for managing neuralgic pain:

  • Anticonvulsants (Anti-seizure Medications): Drugs like carbamazepine, oxcarbazepine, gabapentin, and pregabalin are often first-line treatments for many types of neuralgia, especially trigeminal neuralgia, as they help stabilize nerve membranes.
  • Tricyclic Antidepressants (TCAs): Amitriptyline, nortriptyline, and desipramine can be effective for various neuropathic pain conditions, including some neuralgias.
  • Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Duloxetine and venlafaxine are also used for neuropathic pain.
  • Analgesics:
    • Simple analgesics like acetaminophen or NSAIDs (e.g., ibuprofen, naproxen) may provide some relief for milder pain or if there's an inflammatory component, but are often insufficient for severe neuralgic pain.
    • Opioid analgesics are generally reserved for severe, acute pain or for refractory chronic pain under strict medical supervision due to risks of dependence and side effects.
  • Topical Agents: Capsaicin cream, lidocaine patches or creams can provide localized relief for some peripheral neuralgias.
  • Antiviral Drugs: For herpes zoster-related neuralgia (acute shingles or postherpetic neuralgia), antiviral medications (acyclovir, valacyclovir, famciclovir) are crucial if started early during the acute rash.
  • Muscle Relaxants: May be helpful if muscle spasm contributes to nerve irritation (e.g., in some occipital neuralgias).
  • Vitamins: B-complex vitamins ("B"), Vitamin C ("C"), and Vitamin E ("E") are sometimes prescribed as supportive therapy for nerve health, though evidence for their direct efficacy in treating established neuralgia is often limited unless a specific deficiency is present.
  • Homeopathic Remedies: Some individuals explore homeopathic treatments, but their effectiveness for neuralgia is not supported by robust scientific evidence.

 

Interventional and Rehabilitative Therapies

  • Acupuncture: Can be effective for pain relief in various types of neuralgia.
  • Nerve Blocks: Injection of local anesthetic and/or corticosteroid around the affected nerve or ganglion can provide significant temporary or sometimes prolonged pain relief and can also be diagnostic. Examples include occipital nerve blocks, trigeminal nerve branch blocks, intercostal nerve blocks.
  • Nerve Stimulation Techniques:
    • Transcutaneous Electrical Nerve Stimulation (TENS): Non-invasive, applies mild electrical current to the skin over or near the painful area.
    • Peripheral Nerve Stimulation (PNS): Involves implanting small electrodes near the affected nerve.
    • Spinal Cord Stimulation (SCS): For more widespread or refractory pain.
  • Physiotherapy: In addition to exercises, modalities like ultrasound or laser therapy may be used. Elimination of pain and restoration of sensitivity in conditions like intercostal neuralgia can be accelerated with physiotherapy.
  • Radiofrequency Ablation/Neurotomy: A procedure that uses heat generated by radio waves to destroy nerve fibers transmitting pain signals. Used for certain refractory neuralgias (e.g., trigeminal, facet joint mediated pain).

The elimination of pain and restoration of normal sensation in conditions such as intercostal neuralgia can be significantly accelerated with the use of appropriate physiotherapy techniques and modalities.

Surgical Intervention

Surgical treatment is considered if conservative and interventional therapies are ineffective, or if there is a clear surgically correctable cause (e.g., tumor compressing a nerve, significant vascular compression of the trigeminal nerve).

  • Microvascular Decompression (MVD): For trigeminal neuralgia or glossopharyngeal neuralgia caused by vascular compression of the nerve root. Involves surgically separating the offending blood vessel from the nerve.
  • Neurolysis: Surgical freeing of a nerve trunk from adhesions or scar tissue that may be causing compression or irritation.
  • Nerve Sectioning or Rhizotomy (Destructive Procedures): Historically used for intractable pain but less common now due to risks of sensory loss and potential for deafferentation pain. Examples include trigeminal rhizotomy.
  • Excision of tumors or other compressive lesions.

 

Differential Diagnosis of Localized Pain Syndromes

Neuralgic pain needs to be differentiated from other types of pain in the same anatomical region:

Type of Neuralgia (Example) Common Differential Diagnoses
Trigeminal Neuralgia Dental pain (abscess, pulpitis), Temporomandibular joint (TMJ) dysfunction, Atypical facial pain, Cluster headache, Sinusitis, Postherpetic neuralgia (trigeminal distribution), Tumors affecting trigeminal nerve.
Occipital Neuralgia Tension-type headache, Migraine, Cervicogenic headache (referred pain from cervical spine), Cervical radiculopathy, Muscle spasm/myofascial pain in neck/scalp.
Intercostal Neuralgia Rib fracture, Pleurisy, Costochondritis (Tietze's syndrome), Myocardial ischemia (angina/MI - must rule out cardiac causes for chest pain), Pulmonary embolism, Esophageal spasm, Gallbladder pain (if radiating).
Sciatic Nerve Neuralgia (Sciatica) Lumbosacral radiculopathy (herniated disc, spinal stenosis), Piriformis syndrome, Sacroiliac joint dysfunction, Hip joint pathology (arthritis), Vascular claudication, Peripheral polyneuropathy affecting lower limbs.
Glossopharyngeal Neuralgia Trigeminal neuralgia (V3 branch), Eagle syndrome (elongated styloid process), Oropharyngeal cancer, Temporomandibular joint dysfunction referring pain to throat/ear.
Metatarsalgia Morton's neuroma, Stress fracture of metatarsal, Freiberg's disease, Sesamoiditis, Plantar plate tear, Gout, Rheumatoid arthritis.

 

Prognosis and Potential Complications

The prognosis for neuralgia varies widely depending on the underlying cause, the specific nerve involved, the severity of symptoms, and the response to treatment.

  • Some neuralgias may resolve spontaneously or with conservative treatment.
  • Conditions like trigeminal neuralgia can be chronic and relapsing, though many patients achieve good pain control with medication or surgery.
  • Postherpetic neuralgia can be persistent and difficult to treat in some individuals.

Potential complications include:

  • Chronic, debilitating pain impacting quality of life, sleep, mood, and daily function.
  • Sensory loss or dysesthesia in the affected nerve distribution.
  • Side effects from long-term medication use.
  • Complications related to interventional or surgical procedures.
  • Muscle weakness or atrophy if a mixed nerve with motor components is severely affected over time.

 

Prevention Strategies

While not all neuralgias are preventable, some measures can reduce risk:

  • Infection Prevention/Treatment: Prompt treatment of infections like herpes zoster (shingles vaccine is available for older adults to prevent shingles and thus PHN).
  • Trauma Prevention: Taking precautions to avoid injuries.
  • Management of Underlying Conditions: Good control of diabetes, optimal ergonomics for occupational risks.
  • Avoiding Repetitive Strain: For conditions linked to repetitive movements.

 

When to Consult a Specialist (Neurologist, Pain Specialist, Neurosurgeon)

It is important to consult a physician, and often a specialist such as a neurologist, pain management specialist, or neurosurgeon, if you experience:

  • Severe, recurrent, or persistent nerve pain.
  • Pain that is electric shock-like, burning, or stabbing in character.
  • Pain triggered by light touch or specific movements in a distinct nerve distribution.
  • Associated neurological symptoms like weakness, numbness, or changes in reflexes.
  • Pain that does not respond to over-the-counter analgesics.
  • Suspicion of an underlying serious cause (e.g., tumor, infection, significant nerve compression).

An accurate diagnosis of the type and cause of neuralgia is essential for developing an effective and individualized treatment plan.

References

  1. Cruccu G, Finnerup NB, Jensen TS, et al. Trigeminal neuralgia: New classification and diagnostic grading for practice and research. Neurology. 2016 Jul 12;87(2):220-8.
  2. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018 Jan;38(1):1-211. (Includes sections on cranial neuralgias like occipital neuralgia).
  3. Johnson RW, Rice AS. Clinical practice. Postherpetic neuralgia. N Engl J Med. 2014 Oct 16;371(16):1526-33. (Context for intercostal neuralgia due to herpes zoster).
  4. Koopman JS, Dieleman JP, Huygen FJ, de Mos M, Martin CG, Sturkenboom MC. Incidence of facial pain in the general population. Pain. 2009 Nov;147(1-3):122-7.
  5. Nurmikko TJ, Eldridge PR. Trigeminal neuralgia--pathophysiology, diagnosis and current treatment. Br J Anaesth. 2001 Jul;87(1):117-32.
  6. Vanelderen P, Rouwette T, De Vooght P, et al. Occipital neuralgia: a systematic review. Pain Physician. 2010 Nov-Dec;13(6):555-67.
  7. Jundt JS, Gutta R. Glossopharyngeal neuralgia. Oral Maxillofac Surg Clin North Am. 2012 Nov;24(4):627-35.
  8. Merskey H, Bogduk N, eds. Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms. 2nd ed. IASP Press; 1994. (Definitions and classifications of neuralgic pain).

See also