Cytokeratin-19 fragment (CYFRA 21-1)
Cytokeratin-19 fragment (CYFRA 21-1)
Indications for cytokeratin-19 fragment (CYFRA 21-1) test:
- Non-small cell lung carcinoma and squamous cell lung carcinoma
- Monitoring of muscle-invasive bladder carcinoma
Cytokeratins — insoluble proteins of the cell skeleton, they are known more than 20. Cytokeratin-19 fragment (CYFRA 21-1) are soluble in the serum, have a molecular weight of 30,000 Da. In the test for a tumor marker used 2 monoclonal antibodies for the detection of a fragment of cytokeratin-19 fragment (CYFRA 21-1).
The norm of this tumor marker is 2.3 ng/ml.
Elevated levels of cytokeratin-19 fragment (CYFRA 21-1) are found in non-small cell lung carcinoma, squamous cell lung carcinoma, in muscle-invasive bladder carcinoma. A slight increase (up to 10 ng/ml) is observed in benign liver diseases and renal failure. It should be noted that contamination of blood samples by saliva leads to inflated results.
See also
- Complete blood count (CBC):
- Urinalysis:
- Cerebrospinal fluid (CSF) analysis
- Biochemical markers of bone remodeling and diseases
- Markers of autoimmune connective tissue diseases (CTDs)
- Antiphospholipid syndrome (APS)
- Lipoprotein(a), Lp(a)
- Semen analysis (sperm count test)
- Tumor markers tests (cancer biomarkers):
- β-2 microglobulin (beta-2)
- Alpha-fetoprotein (AFP)
- Squamous cell carcinoma antigen (SCC)
- S100 protein tumormarker
- Calcitonin
- Mucin-like carcinoma-associated antigen (MCA)
- Neuron-specific enolase (NSE)
- Prostate-specific antigen (PSA) test
- Cancer associated antigen 549 (CA 549)
- CA 19-9, CA 72-4, CA 50, CA 15-3 and CA 125 tumor markers (cancer antigens)
- Carcinoembryonic antigen (CEA)
- Thyroglobulin (Tg)
- Tissue polypeptide antigens (ТРА, TPS)
- Cytokeratin-19 fragment (CYFRA 21-1)
- Human chorionic gonadotrophin (hCG)
