Cardiloid

Cardiloid - General Information

A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)

Pharmacology of Cardiloid

Cardiloid is a vasodilator with general properties similar to nitroglycerin.

Additional information about Cardiloid

Cardiloid Indication: For the prevention of angina.
Mechanism Of Action: Similar to other nitrites and organic nitrates, erythrityl tetranitrate is converted to an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Drug Interactions: Not Available
Food Interactions: Avoid alcohol.
Take on empty stomach: 1 hour before or 2 hours after meals.
Generic Name: Erythrityl Tetranitrate
Synonyms: 1,2,3,4-Butanetetralyl tetranitrate; ETN; Eritritile tetranitrato [dcit]; Eritrityl tetranitrate; Eritrityli tetranitras [inn-latin]; Erythritol tetranitrate; Erythrol tetranitrate; Meso-erythritol tetranitrate; Nitroerythrit; Nitroerythrite; Nitroerythrol; Tetranitrate d'eritrityle [inn-french]; Tetranitrato de eritritilo [inn-spanish]
Drug Category: Vasodilator Agents; Nitrates and Nitrites
Drug Type: Small Molecule; Approved

Other Brand Names containing Erythrityl Tetranitrate: Tetranitrin; Tetranitrol; Cardilate; Cardiloid; Cardivell; Cardiwell;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Cardiloid: Not Available
Chemical IUPAC Name: 1,3,4-trinitrooxybutan-2-yl nitrate
Chemical Formula: C4H6N4O12
Erythrityl Tetranitrate on Wikipedia: Not Available
Organisms Affected: Humans and other mammals