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Enbrel Side Effects Center: Detailed Datasheet

Medically reviewed by Min Clinic Staff | Updated: January 2026
  • Generic Name: etanercept
  • Brand Name: Enbrel

Enbrel (Etanercept) side effects drug center

 

PROFESSIONAL

CONSUMER

SIDE EFFECTS

 

Enbrel Side Effects Center

What Is Enbrel?

Enbrel (etanercept) is a tumor necrosis factor inhibitor used to treat certain autoimmune disorders such as rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and plaque psoriasis.

What Are Side Effects of Enbrel?

Common side effects of Enbrel include:

  • Mild nausea
  • Diarrhea
  • Stomach pain
  • Headache
  • Redness or discomfort at the injection site
  • Weight changes
  • Cold symptoms (cough, runny nose)

Serious side effects include:

  • Seizures
  • Bruising
  • Bleeding
  • Skin changes (rash, pustules, blisters, patchy skin color, red spots, or a butterfly-shaped rash over cheeks and nose)
  • Swelling
  • Difficulty breathing or swallowing
  • Numbness and tingling, burning pain
  • Vision changes
  • Dizziness
  • Signs of infection (fever, chills, sore throat, body aches, confusion, neck stiffness, flu symptoms, itching, swelling, warmth, redness, or oozing),
  • Rapid weight gain
  • Chest pain
  • Ongoing cough
  • Coughing up mucus or blood
  • Black, bloody, or tarry stools
  • Changes in mood or personality (in children)