Carbonyl Iron

Carbonyl iron is used as a dietary iron supplement and to treat iron deficiency anemia.

Carbonyl iron is available under the following different brand names: Feosol (Carbonyl Fe), Icar C, Icar Pediatric, and Irco.

Adult and Pediatric Dosage Forms and Strengths

Tablet

• 45 mg (Feosol)
• 66 mg (Ircon)

Oral Suspension

• 15mg/1.25mL (Icar Pediatric)

Tablet, Chewable

• 15mg (Icar Pediatric, Wee Care)

Tablet with Vitamin C

• 100mg iron/250mg vitamin C (Icar C)

Dosage Considerations – Should be Given as Follows:

Dietary Iron Supplement

• Doses expressed as elemental iron unless otherwise noted
• Adults and children over 12 years old:
  • Male: 8 mg orally once daily
  • Female: 18 mg orally once daily
  • Pregnant female: 27 mg orally once daily
  • Lactating female 9 mg orally once daily

• Adults over 50 years old: 8 mg orally once daily
• Children 8-12 years old: 8 mg orally once daily
• Children 3-8 years old: 10 mg orally once daily
• Children 1-3 years old: 7 mg orally once daily
• Children 7-12 months old: 11 mg orally once daily
• Children 0-6 months old: 0.27 mg orally once daily (adequate intake)

Iron Deficiency Anemia

• Adult: 300 mg orally every 12 hours; may increase to 300 mg every 6 hours or 250 mg ER orally every 12 hours
• Severe iron deficiency anemia, pediatric: 4-6 mg/kg orally divided every 8 hours
• Mild to moderate iron deficiency anemia, pediatric: 3 mg/kg orally once daily or divided every 12 hours
• Note: Dose expressed as ferrous sulfate

Prophylaxis of Iron Deficiency

• Adult: 300 mg orally once daily
• Pediatric: 1-2 mg/kg orally; 15 mg orally maximum
• Note: Dose expressed as ferrous sulfate

Side effects of Carbonyl Iron may include.

• Constipation
• Diarrhea
• Nausea
• Upper abdominal pain
• Dark stools
• Vomiting
• Dark stools

Other side effects of carbonyl iron include:

• Hemosiderosis (during long-term administration of large amounts)
• Urine discoloration
• Dental stain by some formulations
• Heartburn

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

• Carbonyl iron has no listed severe interactions with other drugs.
• Serious interactions of carbonyl iron include:
  • baloxavir marboxil
  • ciprofloxacin
  • demeclocycline
  • doxycycline
  • eltrombopag
  • fleroxacin
  • gemifloxacin
  • levofloxacin
  • minocycline
  • moxifloxacin
  • mycophenolate
  • ofloxacin
  • oxytetracycline
  • tetracycline
• Carbonyl iron has moderate interactions with at least 31 different drugs.
• Mild interactions of carbonyl iron include:
  • calcium acetate
  • calcium carbonate
  • calcium chloride
  • calcium citrate
  • calcium gluconate
  • gymnema
  • manganese
  • vitamin E

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

This medication contains carbonyl iron. Do not take Feosol (Carbonyl Fe), Icar C, Icar Pediatric, or Irco if you are allergic to carbonyl iron or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Black Box Warnings

• Severe iron toxicity may occur in overdose, especially when ingested by children.
• Nonintentional iron overdose is the leading cause of fatal poisoning in children younger than 6 years. Keep out of reach of children.

Contraindications

• Hypersensitivity
• Hemochromatosis, hemolytic anemia or anemia not associated with iron deficiency
• Peptic ulcer, regional enteritis, ulcerative colitis

Effects of Drug Abuse

• No information available.

Short-Term Effects

• See "What Are Side Effects Associated with Using Carbonyl Iron?"

Long-Term Effects

• Hemosiderosis (during long-term administration of large amounts)
• Avoid administering iron for more than 6 months except in patients with continuous bleeding or menorrhagia
• See "What Are Side Effects Associated with Using Carbonyl Iron?"

Cautions

• Do not take within 2 hours of oral tetracycline antibiotics
• Not for use in patients receiving frequent blood transfusions
• Avoid in premature infants until their deficient vitamin E stores at birth are replenished
• Avoid administering iron for more than 6 months except in patients with continuous bleeding or heavy menstrual periods (menorrhagia)
• May cause increased red cell hemolysis and hemolytic anemia in infants with low serum vitamin E concentrations

Pregnancy and Lactation

There is no information available on use of carbonyl iron during pregnancy. Consult your doctor.

Carbonyl iron is excreted in breast milk. Consult your doctor before breastfeeding.