Zorane
Zorane - General Information
Zorane (marketed by King Pharmaceuticals under the brand name Skelaxin®) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. Skelaxin comes in an 800 mg scored tablet. It previously came in both 400 mg and 800 mg tablets. The 400 mg tablet has been discontinued. Possible side effects include nausea, vomiting, drowsiness and CNS side effects such as dizziness, headache, and irritability.
Pharmacology of Zorane
Zorane is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Zorane does not directly relax tense skeletal muscles in man.
Zorane for patients
Patient Information:
Use Metaxalone with caution. It may affect driving, operating machinery or other hazarous activities. Metaxalone may increase the effects of alcohol
and other central nervous system depressants.
If you have liver problems or you are breast feeding, discuss with your doctor about the risks of taking the Metaxalone.
Zorane Interactions
SKELAXIN may enhance the effects of alcohol, barbiturates and other CNS depressants.
Zorane Contraindications
Known hypersensitivity to any components of this product.
Known tendency to drug induced, hemolytic, or other anemias.
Significantly impaired renal or hepatic function.
Additional information about Zorane
Zorane Indication: For the treatment of painful musculoskeletal conditions
Mechanism Of Action: The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Metaxalone
Synonyms: Metassalone [Dcit]; Metaxalon; Metaxalona [Inn-Spanish]; Metaxalonum [Inn-Latin]; Metaxalonum [Latin]; Methaxalonum; Methoxolone; Metazalone; Metazolone
Drug Category: Muscle Relaxants, skeletal muscle; Analgesics; Hypnotics and Sedatives
Drug Type: Small Molecule; Approved
Other Brand Names containing Metaxalone: Skelaxin; Zorane;
Absorption: The absolute bioavailability of metaxalone from Skelaxin tablets is not known.
Toxicity (Overdose): LD50=775mg/kg (Rat, oral); LD50=1690 mg/kg (Mouse, oral). When determining the LD50 in rats and mice, progressive sedation, hypnosis and finally respiratoryfailure were noted as the dosage increased. In dogs, no LD50 could be determined as the higher doses produced an emetic action in 15 to 30 minutes.
Protein Binding: Not Available
Biotransformation: Probably hepatic.
Half Life: 9.2 (+/- 4.8) hours
Dosage Forms of Zorane: Tablet Oral
Chemical IUPAC Name: 5-[(3,5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
Chemical Formula: C12H15NO3
Metaxalone on Wikipedia: https://en.wikipedia.org/wiki/Metaxalone
Organisms Affected: Humans and other mammals