Zorane: Full Drug Profile

Zorane - General Information

Zorane (marketed by King Pharmaceuticals under the brand name Skelaxin®) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. Skelaxin comes in an 800 mg scored tablet. It previously came in both 400 mg and 800 mg tablets. The 400 mg tablet has been discontinued. Possible side effects include nausea, vomiting, drowsiness and CNS side effects such as dizziness, headache, and irritability.

Pharmacology of Zorane

Zorane is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Zorane does not directly relax tense skeletal muscles in man.

Zorane for patients

Patient Information:

Use Metaxalone with caution. It may affect driving, operating machinery or other hazarous activities. Metaxalone may increase the effects of alcohol
and other central nervous system depressants.

If you have liver problems or you are breast feeding, discuss with your doctor about the risks of taking the Metaxalone.

Zorane Interactions

SKELAXIN may enhance the effects of alcohol, barbiturates and other CNS depressants.

Zorane Contraindications

Known hypersensitivity to any components of this product.
Known tendency to drug induced, hemolytic, or other anemias.
Significantly impaired renal or hepatic function.

Additional information about Zorane

Zorane Indication

For the treatment of painful musculoskeletal conditions

Mechanism Of Action

The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression.

Generic Name

Metaxalone

Synonyms

Metassalone [Dcit]; Metaxalon; Metaxalona [Inn-Spanish]; Metaxalonum [Inn-Latin]; Metaxalonum [Latin]; Methaxalonum; Methoxolone; Metazalone; Metazolone

Drug Category

Muscle Relaxants, skeletal muscle; Analgesics; Hypnotics and Sedatives

Drug Type

Small Molecule; Approved

Other Brand Names containing Metaxalone

Skelaxin; Zorane;

Absorption

The absolute bioavailability of metaxalone from Skelaxin tablets is not known.

Toxicity (Overdose)

LD₅₀=775mg/kg (Rat, oral); LD₅₀=1690 mg/kg (Mouse, oral). When determining the LD₅₀ in rats and mice, progressive sedation, hypnosis and finally respiratoryfailure were noted as the dosage increased. In dogs, no LD₅₀ could be determined as the higher doses produced an emetic action in 15 to 30 minutes.

Biotransformation

Probably hepatic.

Half Life

9.2 (+/- 4.8) hours

Dosage Forms of Zorane

Tablet Oral

Chemical IUPAC Name

5-[(3,5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one

Chemical Formula

C12H15NO3

Metaxalone on Wikipedia

https://en.wikipedia.org/wiki/Metaxalone

Organisms Affected

Humans and other mammals