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Loribid: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Loribid - General Information

Loribid is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid.

 

Pharmacology of Loribid

Loribid is considered a second generation cephalosporin antibiotic. The advantages of cephalosporin antibiotics include a broad range of activity, a safe record in children with almost no dose-related toxicity, and the lack of need to monitor levels. Adverse reactions are rare and consist primarily of hypersensitivity reactions with urticaria, nonspecific rash, and pruritus. Loribid can be used to treat a large number of bacterial infections caused by gram-negative and gram-positive bacteria, including upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus, S. saprphyticus, S. penumoniae, H. influenzae and M. catarrhalis.

 

Loribid for patients

Loracarbef is an antibiotic used to treat infections such as bronchitis, sinusitis, pneumonia and tonsillitis. This drug should not be used by those with allergies to the cephalosporin antibiotics. You should also consult with your pharmacist or physician if you are allergic to penicillin before taking this medication. This medication shold be taken at least one hour prior to eating or at least 2 hours after eating. The most common side effects are rash, diarrhea and abdominal pain. You should discontinue the medication if you develop a skin rash.

 

Loribid Interactions

Probenecid: As with other b-lactam antibiotics, renal excretion of loracarbef is inhibited by probenecid and resulted in an approximate 80% increase in the AUC for loracarbef.

 

Loribid Contraindications

Loracarbef is contraindicated in patients with known allergy to loracarbef or cephalosporin-class antibiotics.

 

Additional information about Loribid

Loribid Indication

Used to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus, S. saprphyticus, S. penumoniae, H. influenzae and M. catarrhalis.

Mechanism Of Action
Loribid is an oral, synthetic beta-lactam antibiotic of the carbacephem class. Chemically, carbacephems differ from cephalosporin-class antibiotics in the dihydrothiazine ring where a methylene group has been substituted for a sulfur atom. Loribid has a spectrum of activity similar to that of the second generation cephalosporins. It is structurally identical to cefaclor except for a sulfur atom that has been replaced by a methylene group. This change gives greater chemical stability in solution and allows storage at room temperature. Loribid, like all b-lactams and cephalosporins, inhibits penicillin binding proteins, enzymes that create the cross-linkage of the peptidoglycan polymer. This binding leads to interference with the formation and remodeling of the cell wall structure.
Drug Interactions
Probenecid Probenecid increases the antibiotic's level
Food Interactions
Take on an empty stomach. Food reduces Cmax by 50 to 60%.
Generic Name
Loracarbef
Synonyms
Loracarbefum [INN-Latin]
Drug Category
Antibiotics; Anti-Infective Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Loracarbef
Lorabid; Loribid;
Absorption
Well absorbed with approximately 90% absorbed from the gastrointestinal tract after oral ingestion.
Toxicity (Overdose)
Adverse effects include diarrhea, nausea, stomach upset, vomiting, headache, dizziness, rash, bone marrow depression.
Protein Binding
25%
Biotransformation
There is no evidence of metabolism in humans.
Half Life
1 hour. In subjects with moderate impairment of renal function the plasma half-life was prolonged to approximately 5.6 hours.
Dosage Forms of Loribid
Capsule Oral
Chemical IUPAC Name
7-[(2-amino-2-phenylacetyl)amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula
C16H16ClN3O4
Organisms Affected
Various gram-negative and gram-positive eubacteria