Levatol: Full Drug Profile

Levatol - General Information

Levatol is a medication in the class of beta blockers, used in the treatment of high blood pressure. [Wikipedia]

Pharmacology of Levatol

Levatol is a non-selective beta blocker. Beta-blockers work by affecting the response to some nerve impulses in certain parts of the body. As a result, they decrease the heart's need for blood and oxygen by reducing its workload. They also help the heart to beat more regularly.

Additional information about Levatol

Levatol Indication

Used in the treatment of high blood pressure.

Mechanism Of Action

Levatol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension.

Generic Name

Penbutolol

Synonyms

Penbutolol sulfate

Drug Category

Adrenergic beta-Antagonists; Antihypertensive Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Penbutolol

Betapressin; Levatol; Levatolol; Lobeta; Paginol;

Absorption

Oral bioavailability is 90%.

Toxicity (Overdose)

Symptoms of overdose include drowsiness, vertigo, headache, and atriventricular block.

Protein Binding

80-98% bound to plasma proteins.

Biotransformation

Metabolized in the liver by hydroxylation and glucuroconjugation forming a glucuronide metabolite and a semi-active 4-hydroxy metabolite.

Half Life

Phase 1: 2.5 hours; phase 2: 24 hours

Dosage Forms of Levatol

Tablet Oral

Chemical IUPAC Name

(2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol

Chemical Formula

C18H29NO2

Penbutolol on Wikipedia

https://en.wikipedia.org/wiki/Penbutolol

Organisms Affected

Humans and other mammals