Ilvin
Ilvin - General Information
Ilvin maleate is an antihistamine used to treat allergic conditions such as hay fever or urticaria.
Pharmacology of Ilvin
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Ilvin is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Ilvin for patients
Take with food, water, or milk to minimize gastric irritation. Swallow the extended-release dosage form whole (do not crush). If you miss a dose, take as soon as possible but do not take if it is almost time for your next dose. DO NOT double up on doses. Notify your doctor if skin tests using allergens is required as this medication may interfere with test results. Avoid use of alcohol or other CNS depressants while taking this medication. This medication can cause drowsiness or dizziness. Use caution while taking this medicine when driving or using equipment. Talk to your doctor if you are taking appetite suppressants. This medication can cause insomnia. Take the medication a few hours before bedtime if this occurs. This medication can cause dryness of mouth - use sugarless gum, candy, ice, or saliva substitute for relief. Check with your dentist if dry mouth continues for more than 2 weeks.
Ilvin Interactions
Dexbrompheniramine can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).
Ilvin Contraindications
Contraindicated in the following: blood disease, heart or blood vessel disease (may cause more serious conditions to develop), enlarged prostate, urinary tract blockage or difficult urination (antihistamines may cause urinary problems to become worse), epilepsy (antihistamines may increase the chance of seizures), glaucoma (may cause a slight increase in inner eye pressure that may worsen the condition, jaundice (antihistamines may make the condition worse), liver disease (antihistamines may build up in the body, which may increase the chance of side effects such as muscle spasms), Reye's syndrome (antihistamines may increase the chance of uncontrolled movements).
Additional information about Ilvin
Ilvin Indication: For treatment and relief of symptoms of allergies, hay fever, and colds
Mechanism Of Action: Ilvin competitively binds to the histamine H1-receptor. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dexbrompheniramine
Synonyms: D-Brompheniramine; Parabromdylamine; Parabromodylamine
Drug Category: Antihistamines
Drug Type: Small Molecule; Approved
Other Brand Names containing Dexbrompheniramine: Ilvin;
Absorption: Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
Toxicity (Overdose): Signs of an overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
Protein Binding: Not Available
Biotransformation: Hepatic (cytochrome P-450 system), some renal.
Half Life: 25 hours
Dosage Forms of Ilvin: Not Available
Chemical IUPAC Name: (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Chemical Formula: C16H19BrN2
Dexbrompheniramine on Wikipedia: https://en.wikipedia.org/wiki/Dexbrompheniramine
Organisms Affected: Humans and other mammals
