Sinequan (doxepin) is a tricyclic antidepressant used to treat symptoms of depression and/or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions. The brand name Sinequan is discontinued in the U.S. Generic forms are available.
Suicidal thinking and behavior may occur in children, adolescents, and young adults taking Sinequan. Tell your doctor immediately if you have suicidal thoughts while taking Sinequan.
Dosage for Sinequan
For most patients with illness of mild to moderate severity, a starting daily dose of 75 mg doxepin is recommended. The usual optimum dose range is 75 mg/day to 150 mg/day.
What Drugs, Substances, or Supplements Interact with Sinequan?
Doxepin may interact with SSRIantidepressants, cimetidine, or heart rhythm medications. Tell your doctor all medications you use.
Sinequan During Pregnancy or Breastfeeding
During pregnancy, doxepin should be used only when prescribed. Since untreated depression can be a serious condition, do not stop using this medication unless directed by your doctor. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breastfeeding while using this drug is not recommended.
Additional Information
Our Sinequan (doxepin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Sinequan Consumer Information
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
blurred vision, tunnel vision, eye pain or swelling, seeing halos around lights;
a light-headed feeling, like you might pass out;
tremors, restless muscle movements in your eyes, tongue, jaw, or neck;
severe constipation;
confusion, hallucinations, unusual thoughts, seizure (convulsions); or
painful or difficult urination.
Common side effects may include:
drowsiness, dizziness;
increased blood pressure;
vision changes;
rash, swelling;
nausea, vomiting, indigestion;
little or no urination;
dry mouth, constipation; or
decreased or increased sex drive.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
NOTE: Some of the adverse reactions noted below
have not been specifically reported with SINEQUAN use. However, due to the
close pharmacological similarities among the tricyclics, the reactions should
be considered when prescribing SINEQUAN (doxepin HCl).
Anticholinergic Effects
Dry mouth, blurred vision, constipation, and urinary
retention have been reported. If they do not subside with continued therapy, or
become severe, it may be necessary to reduce the dosage.
Central Nervous System Effects
Drowsiness is the most commonly noticed side effect. This
tends to disappear as therapy is continued. Other infrequently reported CNS
side effects are confusion, disorientation, hallucinations, numbness,
paresthesias, ataxia, extrapyramidal symptoms, seizures, tardive dyskinesia,
and tremor.
Nausea, vomiting, indigestion, taste disturbances,
diarrhea, anorexia, and aphthous stomatitis have been reported. (See Anticholinergic
Effects.)
Endocrine
Raised or lowered libido, testicular swelling, gynecomastia
in males, enlargement of breasts and galactorrhea in the female, raising or
lowering of blood sugar levels, and syndrome of inappropriate antidiuretic
hormone secretion have been reported with tricyclic administration.
Other
Dizziness, tinnitus, weight gain, sweating, chills,
fatigue, weakness, flushing, jaundice, alopecia, headache, exacerbation of
asthma, angle closure glaucoma, mydriasis and hyperpyrexia (in association with
chlorpromazine) have been occasionally observed as adverse effects.
Withdrawal Symptoms
The possibility of development of withdrawal symptoms
upon abrupt cessation of treatment after prolonged SINEQUAN administration
should be borne in mind. These are not indicative of addiction and gradual
withdrawal of medication should not cause these symptoms.
&Copy; Sinequan Patient Information is supplied by Cerner Multum, Inc. and Sinequan Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
