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Lotensin Hct

  • Generic Name: benazepril hcl and hctz
  • Brand Name: Lotensin Hct

Lotensin Hct (Benazepril HCl and HCTZ) side effects drug center

 

PROFESSIONAL

CONSUMER

SIDE EFFECTS

Lotensin Hct Side Effects Center

Lotensin HCT (benazepril hydrochloride and hydrochlorothiazide) is a combination of an ACE (angiotensin converting enzyme) inhibitor and a thiazide diuretic (water pill) used to treat hypertension (high blood pressure). Lotensin HCT is available in generic form. Common side effects of Lotensin HCT include:

  • dizziness
  • lightheadedness
  • drowsiness
  • headache
  • fatigue
  • tired feeling
  • blurred vision
  • dry cough
  • skin rash
  • increased sweating
  • nausea
  • vomiting
  • constipation as your body adjusts to the medication

Lotensin HCT may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor if you experience extreme thirst, very dry mouth, muscle cramps or weakness, fast/slow/irregular heartbeat, confusion, or decreased urination.

The recommended dosage of Lotensin HCT ranges between 5 mg/6.25 mg (benazepril/hydrochlorothiazide) and 20 mg/25 mg once a day. Dosage may be increased or decreased based on the patient's response. Lotensin HCT may interact with other diuretics (water pills) or blood pressure medications, gold injections for arthritis, lithium, digoxin, cholestyramine, colestipol, steroids, NSAIDs (non-steroidal anti-inflammatory drugs), or insulin or oral diabetes medicine. Tell your doctor all medications you use. Lotensin HCT is not recommended during pregnancy due to the risk for harm to a fetus. A small amount of this drug passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breastfeeding.

Our Lotensin HCT (benazepril hydrochloride and hydrochlorothiazide USP) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

 

Lotensin Hct Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

You may be more likely to have an allergic reaction if you are African-American.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • jaundice (yellowing of the skin or eyes);
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • fever, chills, flu-like symptoms, sore throat, mouth sores;
  • signs of an electrolyte imbalance--leg cramps, constipation, muscle pain or weakness, irregular heartbeats, feeling jittery, increased thirst or urination, numbness or tingling, loss of movement;
  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or
  • new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Common side effects may include:

  • dizziness;
  • cough;
  • headache; or
  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lotensin Hct (Benazepril HCl and HCTZ)

 

Lotensin Hct Professional Information

SIDE EFFECTS

Lotensin HCT has been evaluated for safety in over 2500 patients with hypertension; over 500 of these patients were treated for at least 6 months, and over 200 were treated for more than 1 year.

The reported side effects were generally mild and transient, and there was no relationship between side effects and age, sex, race, or duration of therapy. Discontinuation of therapy due to side effects was required in approximately 7% of U.S. patients treated with Lotensin HCT and in 4% of patients treated with placebo.

The most common reasons for discontinuation of therapy with Lotensin HCT in U.S. studies were cough (1.0%; see PRECAUTIONS), “dizziness” (1.0%), headache (0.6%), and fatigue (0.6%).

The side effects considered possibly or probably related to study drug that occurred in U.S. placebo-controlled trials in more than 1% of patients treated with Lotensin HCT are shown in the table below.

Reactions Possibly or Probably Drug Related
Patients in U.S. Placebo-Controlled Studies

  LOTENSIN HCT
N = 665		 Placebo
N = 235
N % N %
“Dizziness” 41 6.3 8 3.4
Fatigue 34 5.2 6 2.6
Postural Dizziness 23 3.5 1 0.4
Headache 20 3.1 10 4.3
Cough 14 2.1 3 1.3
Hypertonia 10 1.5 3 1.3
Vertigo 10 1.5 2 0.9
Nausea 9 1.4 2 0.9
Impotence 8 1.2 0 0.0
Somnolence 8 1.2 1 0.4

Other side effects considered possibly or probably related to study drug that occurred in U.S. placebo-controlled trials in 0.3% to 1.0% of patients treated with Lotensin HCT were the following:

Cardiovascular: Palpitations, flushing.

Gastrointestinal: Vomiting, diarrhea, dyspepsia, anorexia, and constipation.

Neurologic and Psychiatric: Insomnia, nervousness, paresthesia, libido decrease, dry mouth, taste perversion, and tinnitus.

Dermatologic: Rash and sweating.

Other: Urinary frequency, arthralgia, myalgia, asthenia, and pain (including chest pain and abdominal pain).

Other adverse experiences reported in 0.3% or more of Lotensin HCT patients in U.S. controlled clinical trials, and rarer events seen in post-marketing experience, were the following; asterisked entries occurred in more than 1% of patients (in some, a causal relationship to Lotensin HCT is uncertain):

Cardiovascular: Syncope, peripheral vascular disorder, and tachycardia.

Body as a Whole: Infection, back pain*, flu syndrome*, fever, chills, and neck pain.

Dermatologic: Photosensitivity and pruritus.

Gastrointestinal: Gastroenteritis, flatulence, and tooth disorder.

Neurologic and Psychiatric: Hypesthesia, abnormal vision, abnormal dreams, and retinal disorder.

Respiratory: Upper respiratory infection*, epistaxis, bronchitis, rhinitis*, sinusitis*, and voice alteration.

Other: Conjunctivitis, arthritis, urinary tract infection, alopecia, and urinary frequency*.

Post-Marketing Experience

The following adverse reactions have been identified during post-approval use of either benazapril or hydrochlorothiazide. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency or establish a causal relationship to drug exposure:

Benazepril

Stevens-Johnson syndrome, pancreatitis, hemolytic anemia, pemphigus, and thrombocytopenia, eosinophilic pneumonitis

Hydrochlorothiazide

Digestive: Pancreatitis, small bowel angioedema, jaundice (intrahepatic cholestatic), sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation, and anorexia.

Neurologic: Vertigo, lightheadedness, transient blurred vision, headache, paresthesia, xanthopsia, weakness, and restlessness.

Musculoskeletal: Muscle spasm. Hematologic: Aplastic anemia, agranulocytosis, leukopenia, neutropenia and thrombocytopenia.

Metabolic: Hyperglycemia, glycosuria, and hyperuricemia, pyrexia, asthenia, parathyroid gland changes with hypercalcemia and hypophosphatemia.

Hypersensitivity: Anaphylactoid reactions, necrotizing angiitis, respiratory distress (including pneumonitis and pulmonary edema), purpura, urticaria, rash, and photosensitivity.

Skin: Erythema multiforme including Stevens-Johnson syndrome, and exfoliative dermatitis including toxic epidermal necrolysis.

Clinical Laboratory Test Findings

Serum Electrolytes

See PRECAUTIONS.

Creatinine and BUN

Minor reversible increases in serum creatinine and BUN were observed in patients with essential hypertension treated with Lotensin HCT. Such increases occurred most frequently in patients with renal artery stenosis (see PRECAUTIONS).

Read the entire FDA prescribing information for Lotensin Hct (Benazepril HCl and HCTZ)

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&Copy; Lotensin Hct Patient Information is supplied by Cerner Multum, Inc. and Lotensin Hct Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.