Trulicity vs. Januvia

• Are Trulicity and Januvia the Same Thing?
• What Are Possible Side Effects of Trulicity?
• What Are Possible Side Effects of Januvia?
• What Is Trulicity?
• What Is Januvia?
• What Drugs Interact with Trulicity?
• What Drugs Interact with Januvia?
• How Should Trulicity Be Taken?
• How Should Januvia Be Taken?

Trulicity (dulaglutide) and Januvia (sitagliptin) are diabetes medications used as adjuncts to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Trulicity and Januvia are different types of diabetes medications. Trulicity is a human GLP-1 receptor agonist and Januvia is a DPP-4 inhibitor.

Side effects of Trulicity and Januvia that are similar include nausea, abdominal or stomach pain or discomfort, diarrhea, constipation, and low blood sugar (hypoglycemia).

Side effects of Trulicity that are different from Januvia include vomiting, decreased appetite, indigestion, frequent bowel movements, fatigue, gas, bloating, gastroesophageal reflux disease (GERD), weakness/lack of energy, feeling unwell (malaise), and belching.

Side effects of Januvia that are different from Trulicity include runny or stuffy nose, sore throat, headache, back pain, and joint or muscle pain.

Trulicity may interact with other oral medications taken at the same time.

Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers.

Common side effects of Trulicity include:

• nausea,
• diarrhea,
• frequent bowel movements,
• vomiting,
• abdominal pain or discomfort,
• decreased appetite,
• indigestion,
• fatigue,
• constipation,
• gas,
• bloating,
• gastroesophageal reflux disease (GERD),
• weakness/lack of energy,
• feeling unwell (malaise),
• belching, and
• low blood sugar (hypoglycemia).

Common side effects of Januvia include:

• runny or stuffy nose,
• sore throat,
• headache,
• back pain,
• joint or muscle pain,
• nausea,
• stomach pain,
• diarrhea, or
• constipation.

Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet.

Trulicity (dulaglutide) is a human GLP-1 receptor agonist used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Many people using Januvia do not have serious side effects.

Trulicity may interact with other oral medications. Tell your doctor all medications and supplements you use. During pregnancy, Trulicity should be taken only if prescribed; it is unknown if it would affect a fetus. It is unknown if Trulicity passes into breast milk. Consult your doctor before breastfeeding.

Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy Januvia should be used only when prescribed. Pregnancy may cause or worsen diabetes. Your doctor may change your diabetes treatment during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

The recommended initiating dose of Trulicity is 0.75 mg once weekly. The maximum recommended dose is 1.5 mg once weekly.

The recommended dose of Januvia is 100 mg once daily.