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Harvoni vs. Mavyret

Are Harvoni and Mavyret the Same Thing?

Harvoni (ledipasvir and sofosbuvir) and Mavyret (glecaprevir and pibrentasvir) are combinations of antiviral agents used to treat chronic hepatitis C (CHC) genotype 1 infection in adults.

Mavyret is also used to treat chronic HCV genotype (GT) 2, 3, 4, 5 or 6 infection without cirrhosis and with compensated cirrhosis (Child-Pugh A).

Side effects of Harvoni and Mavyret that are similar include fatigue, headache, nausea, diarrhea, and weakness/lack of energy.

Side effects of Harvoni that are different from Mavyret include insomnia.

Both Harvoni and Mavyret may interact with rifampin and St. John's wort.

Mavyret may also interact with carbamazepine, efavirenz, antiarrhythmics, anticoagulants, oral contraceptives, HIV antiviral agents, HMG-CoA reductase inhibitors ("statin" drugs), and cyclosporine.

What Are Possible Side Effects of Harvoni?

Common side effects of Harvoni include:

    • fatigue,
    • headache,
    • nausea,
    • diarrhea,
    • insomnia, and
    • weakness.

    What Are Possible Side Effects of Mavyret?

    Common side effects of Mavyret include:

    • headache,
    • fatigue,
    • nausea,
    • diarrhea, and
    • weakness/lack of energy.

    What Is Harvoni?

    Harvoni (ledipasvir and sofosbuvir) is a direct-acting antiviral agent used to treat chronic hepatitis C (CHC) genotype 1 infection in adults.

    What Is Mavyret?

    Mavyret (glecaprevir and pibrentasvir) tablets are a fixed-dose combination of a hepatitis C virus (HCV) NS3/4A protease inhibitor and an HCV NS5A inhibitor, indicated for the treatment of patients with chronic HCV genotype (GT) 1, 2, 3, 4, 5 or 6 infection without cirrhosis and with compensated cirrhosis (Child-Pugh A). Mavyret is also indicated for the treatment of adult patients with HCV genotype 1 infection, who previously have been treated with a regimen containing an HCV NS5A inhibitor or an NS3/4A protease inhibitor, but not both.

     

    What Drugs Interact With Harvoni?

    Harvoni may interact with rifampin, and St. John's wort. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plant to become pregnant before using Harvoni. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

    What Drugs Interact With Mavyret?

    Mavyret may interact with carbamazepine, efavirenz, St. John's wort, antiarrhythmics, anticoagulants, rifampin, oral contraceptives, HIV antiviral agents, HMG-CoA reductase inhibitors ("statin" drugs), and cyclosporine. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Mavyret; it is unknown how it would affect a fetus. It is unknown if Mavyret passes into breast milk. Consult your doctor before breastfeeding.

     

    How Should Harvoni Be Taken?

    Harvoni is a two-drug fixed-dose combination product that contains 90 mg of ledipasvir and 400 mg of sofosbuvir in a single tablet. The recommended dosage of Harvoni is one tablet taken orally once daily with or without food.

    How Should Mavyret Be Taken?

    All patients are tested for HBV infection prior to initiating therapy with Mavyret by measuring HBsAg and anti-HBc. The recommended dosage of Mavyret is three tablets (total daily dose: glecaprevir 300 mg and pibrentasvir 120 mg) taken orally once daily with food.