Desyrel
- Generic Name: trazodone hydrochloride
- Brand Name: Desyrel
Desyrel (Trazodone Hydrochloride) side effects drug center
Desyrel Side Effects Center
What Is Desyrel?
Desyrel (trazodone hydrochloride) is an antidepressant used to treat depression. The brand name Desyrel is no longer available in the U.S. but may be available in generic form.
What Are Side Effects of Desyrel?
Common side effects of Desyrel (trazodone hydrochloride) include:
- nausea,
- vomiting,
- diarrhea,
- drowsiness,
- dizziness,
- tiredness,
- blurred vision,
- changes in weight,
- headache,
- muscle ache/pain,
- dry mouth,
- bad taste in the mouth,
- stuffy nose,
- constipation, or
- change in sexual interest/ability.
Dosage for Desyrel
The initial adult dose of trazodone is 150 mg/day in divided doses. The dose may be increased by 50 mg/day every three to four days. The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses.
What Drugs, Substances, or Supplements Interact with Desyrel?
Trazodone may interact with HIV medicines, antifungal medications, digoxin, seizure medicines, warfarin, or MAO inhibitors. Tell your doctor all medications you use.
Desyrel During Pregnancy and Breastfeeding
During pregnancy, trazodone should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breastfeeding.
Additional Information
Our Desyrel (trazodone hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Desyrel Consumer Information
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 6 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
- fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);
- slow heartbeats;
- unusual thoughts or behavior;
- easy bruising, unusual bleeding; or
- low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common side effects may include:
- drowsiness, dizziness, tiredness;
- swelling;
- weight loss;
- blurred vision;
- diarrhea, constipation; or
- stuffy nose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Desyrel (Trazodone Hydrochloride)
Desyrel Professional Information
SIDE EFFECTS
The following serious adverse reactions are described elsewhere in the labeling:
- Suicidal Thoughts and Behavior in Children, Adolescents and Young Adults [see BOXED WARNING and WARNINGS AND PRECAUTIONS]
- Serotonin Syndrome [see WARNINGS AND PRECAUTIONS]
- Cardiac Arrythmias (see WARNINGS AND PRECAUTIONS]
- Orthostatic Hypotension and Syncope [see WARNINGS AND PRECAUTIONS]
- Increased Risk of Bleeding [see WARNINGS AND PRECAUTIONS]
- Priapism [see WARNINGS AND PRECAUTIONS]
- Activation of Mania or Hypomania [see WARNINGS AND PRECAUTIONS]
- Discontinuation Syndrome [see WARNINGS AND PRECAUTIONS]
- Potential for Cognitive and Motor Impairment [see WARNINGS AND PRECAUTIONS]
- Angle-Closure Glaucoma [see WARNINGS AND PRECAUTIONS]
- Hyponatremia [see WARNINGS AND PRECAUTIONS]
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Table 2: Common Adverse Reactions Occurring in ≥
2% of DESYREL-treated Patients and Greater than the Rate of Placebo- Treated
Patients as Observed in Controled Clinical Studies
| Inpatients | Outpatients | |||
| Desyrel® N= 142 |
Placebo N=95 |
Desyrel® N=157 |
Placebo N=158 |
|
| Allergic | ||||
| Skin Condition/Edema | 3% | 1% | 7% | 1% |
| Autonomic | ||||
| Blurred Vision | 6% | 4% | 15% | 4% |
| Constipation | 7% | 4% | 8% | 6% |
| Dry Mouth | 15% | 8% | 34% | 20% |
| Cardiovascular | ||||
| Hypertension | 20% | 1% | 1% | * |
| Hypotension | 7% | 1% | 4% | 0 |
| Syncope | 3% | 2% | 5% | 1% |
| CNS | ||||
| Confusion | 5% | 0 | 6% | 8% |
| Decreased Concentration | 3% | 2% | 1% | 0 |
| Disorientation | 2% | 0 | * | 0 |
| Dizziness/Light-Headedness | 20% | 5% | 28% | 15% |
| Drowsiness | 24% | 6% | 41% | 20% |
| Fatigue | 11% | 4% | 6% | 3% |
| Headache | 10% | 5% | 20% | 16% |
| Nervousness | 15% | 11% | 6% | 8% |
| Gastrointestinal | ||||
| Abdominal/Gastric Disorder | 4% | 4% | 6% | 4% |
| Diarrhea | 0 | 1% | 5% | 1% |
| Nausea/Vomiting | 10% | 1% | 13% | 10% |
| Musculoskeletal | ||||
| Aches/Pains | 6% | 3% | 5% | 3% |
| Neurological | ||||
| Incoordination | 5% | 0 | 2% | * |
| Tremors | 3% | 1% | 5% | 4% |
| Other | ||||
| Eyes Red/Tired/Itching | 3% | 0 | 0 | 0 |
| Head Full-Heavy | 3% | 0 | 0 | 0 |
| Malaise | 3% | 0 | 0 | 0 |
| Nasal/Sinus Congestion | 3% | 0 | 6% | 3% |
| Weight Gain | 1% | 0 | 5% | 2% |
| Weight Loss | * | 3% | 6% | 3% |
Other adverse reactions occurring at an incidence of <2% with the use of trazodone hydrochloride in the controlled clinical studies: akathisia, allergic reaction, anemia, chest pain, delayed urine flow, early menses, flatulence, hallucinations/delusions, hematuria, hypersalivation, hypomania, impaired memory, impaired speech, impotence, increased appetite, increased libido, increased urinary frequency, missed periods, muscle twitches, numbness, paresthesia, retrograde ejaculation, shortness of breath, and tachycardia/palpitations. Occasional sinus bradycardia has occurred in long-term studies.
Postmarketing Experience
The following adverse reactions have been identified during post-approval use of DESYREL. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency or establish a causal relationship to drug exposure:
Blood and lymphatic system disorders: hemolytic anemia, leukocytosis
Cardiac disorders: cardiospasm, congestive heart failure, conduction block, orthostatic hypotension and syncope, palpitations, bradycardia, atrial fibrillation, myocardial infarction, cardiac arrest, arrhythmia, ventricular ectopic activity, including ventricular tachycardia and QT prolongation. Prolonged QT interval, torsade de pointes, and ventricular tachycardia have been reported at doses of 100 mg per day or less [see WARNINGS AND PRECAUTIONS].
Endocrine disorders: inappropriate ADH syndrome
Eye disorders: diplopia
Gastrointestinal disorders: increased salivation, nausea/vomiting
General disorders and administration site conditions: chills, edema, unexplained death, weakness
Hepatobiliary disorders: cholestasis, jaundice, hyperbilirubinemia, liver enzyme alterations
Investigations: increased amylase
Metabolism and nutrition disorders: methemoglobinemia
Nervous system disorders: aphasia, ataxia, cerebrovascular accident, extrapyramidal symptoms, grand mal seizures, paresthesia, tardive dyskinesia, vertigo
Psychiatric disorders: abnormal dreams, agitation, anxiety, hallucinations, insomnia, paranoid reaction, psychosis, stupor
Renal and urinary disorders: urinary incontinence, urinary retention
Reproductive system and breast disorders: breast enlargement or engorgement, clitorism, lactation, priapism [see WARNINGS AND PRECAUTIONS]
Respiratory, thoracic and mediastinal disorders: apnea
Skin and subcutaneous tissue disorders: alopecia, hirsutism, leukonychia, pruritus, psoriasis, rash, urticaria
Vascular disorders: vasodilation
Read the entire FDA prescribing information for Desyrel (Trazodone Hydrochloride)
&Copy; Desyrel Patient Information is supplied by Cerner Multum, Inc. and Desyrel Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.