Bromfenex
Bromfenex - General Information
Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Pharmacology of Bromfenex
Bromfenex is an antihistaminergic medication of the propylamine class. It is a first-generation antihistamine. In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Bromfenex is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Bromfenex for patients
Take with food, water, or milk to minimize gastric irritation. Swallow the extended-release dosage form whole (do not crush). If you miss a dose, take as soon as possible but do not take if it is almost time for your next dose. DO NOT double up on doses. Notify your doctor if skin tests using allergens is required as this medication may interfere with test results. Avoid use of alcohol or other CNS depressants while taking this medication. This medication can cause drowsiness or dizziness. Use caution while taking this medicine when driving or using equipment. Talk to your doctor if you are taking appetite suppressants. This medication can cause insomnia. Take the medication a few hours before bedtime if this occurs. This medication can cause dryness of mouth - use sugarless gum, candy, ice, or saliva substitute for relief. Check with your dentist if dry mouth continues for more than 2 weeks.
Bromfenex Interactions
Dexbrompheniramine can interact with alcohol or other CNS depressants (may potentiate the CNS depressant effects of either these medications or antihistamines), anticholinergics or other medications with anticholinergic activity (anticholinergic effects may be potentiated when these medications are used concurrently with antihistamines), and monoamine oxidase (MAO) inhibitors (concurrent use with antihistamines may prolong and intensify the anticholinergic and CNS depressant effects of antihistamines).
Bromfenex Contraindications
Contraindicated in the following: blood disease, heart or blood vessel disease (may cause more serious conditions to develop), enlarged prostate, urinary tract blockage or difficult urination (antihistamines may cause urinary problems to become worse), epilepsy (antihistamines may increase the chance of seizures), glaucoma (may cause a slight increase in inner eye pressure that may worsen the condition, jaundice (antihistamines may make the condition worse), liver disease (antihistamines may build up in the body, which may increase the chance of side effects such as muscle spasms), Reye's syndrome (antihistamines may increase the chance of uncontrolled movements).
Additional information about Bromfenex
Bromfenex Indication: For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.
Mechanism Of Action: Bromfenex works by acting as an antagonist of the H1 histamine receptors. It also functions as a moderately effective anticholingeric agent, likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.
Drug Interactions: Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Rivastigmine Possible antagonism of action
Food Interactions: Take with food.
Avoid alcohol.
Generic Name: Brompheniramine
Synonyms: Brompheniramine Maleate
Drug Category: Anti-Allergic Agents; Histamine H1 Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Brompheniramine: Veltane; Bromfed; Bromfenex; Dimetane;
Absorption: Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
Toxicity (Overdose): Oral, rat: LD50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
Protein Binding: Not Available
Biotransformation: Hepatic (cytochrome P-450 system), some renal.
Half Life: Not Available
Dosage Forms of Bromfenex: Not Available
Chemical IUPAC Name: 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Chemical Formula: C16H19BrN2
Brompheniramine on Wikipedia: https://en.wikipedia.org/wiki/Brompheniramine
Organisms Affected: Humans and other mammals
