Yamatetan
Yamatetan - General Information
A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. [PubChem]
Pharmacology of Yamatetan
Yamatetan is a semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Yamatetan for patients
Patients should be counseled that antibacterial drugs, including CEFOTAN, should only be used to treat bacterial infections. They do not treat viral infections (eg, the common cold). When CEFOTAN is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment, and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by CEFOTAN or other antibacterial drugs in the future.
As with some other cephalosporins, a disulfiram-like reaction characterized by flushing, sweating, headache, and tachycardia may occur when alcohol (beer, wine, etc.) is ingested within 72 hours after CEFOTAN administration. Patients should be cautioned about the ingestion of alcoholic beverages following the administration of CEFOTAN.
Yamatetan Interactions
Increases in serum creatinine have occurred when CEFOTAN was given alone. If CEFOTAN and an aminoglycoside are used concomitantly, renal function should be carefully monitored, because nephrotoxicity may be potentiated.
Drug/Laboratory Test Interactions: The administration of CEFOTAN may result in a false positive reaction for glucose in the urine using Clinitest®†, Benedict's solution, or Fehling's solution. It is recommended that glucose tests based on enzymatic glucose oxidase be used.
As with other cephalosporins, high concentrations of cefotetan may interfere with measurement of serum and urine creatinine levels by Jaffe¢ reaction and produce false increases in the levels of creatinine reported.
Yamatetan Contraindications
CEFOTAN is contraindicated in patients with known allergy to the cephalosporin group of antibiotics and in those individuals who have experienced a cephalosporin associated hemolytic anemia.
Additional information about Yamatetan
Yamatetan Indication: For prophylaxis and treatment of bacterial infections.
Mechanism Of Action: The bactericidal action of cefotetan results from inhibition of cell wall synthesis.
Drug Interactions: Amikacin Increased risk of nephrotoxicity
Anisindione The cephalosporin increases the anticoagulant effect
Dicumarol The cephalosporin increases the anticoagulant effect
Acenocoumarol The cephalosporin increases the anticoagulant effect
Warfarin The cephalosporin increases the anticoagulant effect
Gentamicin Increased risk of nephrotoxicity
Kanamycin Increased risk of nephrotoxicity
Neomycin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Probenecid Probenecid increases the antibiotic's level
Streptomycin Increased risk of nephrotoxicity
Tobramycin Increased risk of nephrotoxicity
Food Interactions: Avoid alcohol as it can cause a disulfiram effect.
Generic Name: Cefotetan
Synonyms: Cefotetanum [inn-latin]
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Cefotetan: Cefotan; Yamatetan;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Cefotetan is 88% plasma protein bound.
Biotransformation: No active metabolites of cefotetan have been detected; however, small amounts (less than 7%) of cefotetan in plasma and urine may be converted to its tautomer, which has antimicrobial activity similar to the parent drug.
Half Life: In volunteers with reduced renal function, the plasma half-life of cefotetan is prolonged
Dosage Forms of Yamatetan: Injection, solution Intravenous
Injection, solution Intramuscular
Chemical IUPAC Name: (7S)-7-[[4-(1-amino-3-hydroxy-1,3-dioxopropan-2-ylidene)1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C17H17N7O8S4
Cefotetan on Wikipedia: https://en.wikipedia.org/wiki/Cefotetan
Organisms Affected: Enteric bacteria and other eubacteria