Yamatetan: Full Drug Profile

Yamatetan - General Information

A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. [PubChem]

 

Pharmacology of Yamatetan

Yamatetan is a semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.

 

Yamatetan for patients

Patients should be counseled that antibacterial drugs, including CEFOTAN, should only be used to treat bacterial infections. They do not treat viral infections (eg, the common cold). When CEFOTAN is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment, and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by CEFOTAN or other antibacterial drugs in the future.

As with some other cephalosporins, a disulfiram-like reaction characterized by flushing, sweating, headache, and tachycardia may occur when alcohol (beer, wine, etc.) is ingested within 72 hours after CEFOTAN administration. Patients should be cautioned about the ingestion of alcoholic beverages following the administration of CEFOTAN.

 

Yamatetan Interactions

Increases in serum creatinine have occurred when CEFOTAN was given alone. If CEFOTAN and an aminoglycoside are used concomitantly, renal function should be carefully monitored, because nephrotoxicity may be potentiated.

Drug/Laboratory Test Interactions: The administration of CEFOTAN may result in a false positive reaction for glucose in the urine using Clinitest®†, Benedict's solution, or Fehling's solution. It is recommended that glucose tests based on enzymatic glucose oxidase be used.

As with other cephalosporins, high concentrations of cefotetan may interfere with measurement of serum and urine creatinine levels by Jaffe¢ reaction and produce false increases in the levels of creatinine reported.

 

Yamatetan Contraindications

CEFOTAN is contraindicated in patients with known allergy to the cephalosporin group of antibiotics and in those individuals who have experienced a cephalosporin associated hemolytic anemia.

 

Additional information about Yamatetan

Yamatetan Indication

For prophylaxis and treatment of bacterial infections.

Mechanism Of Action

The bactericidal action of cefotetan results from inhibition of cell wall synthesis.

Drug Interactions

Amikacin Increased risk of nephrotoxicity

Food Interactions

Avoid alcohol as it can cause a disulfiram effect.

Generic Name

Cefotetan

Synonyms

Cefotetanum [inn-latin]

Drug Category

Anti-Bacterial Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Cefotetan

Cefotan; Yamatetan;

Protein Binding

Cefotetan is 88% plasma protein bound.

Biotransformation

No active metabolites of cefotetan have been detected; however, small amounts (less than 7%) of cefotetan in plasma and urine may be converted to its tautomer, which has antimicrobial activity similar to the parent drug.

Half Life

In volunteers with reduced renal function, the plasma half-life of cefotetan is prolonged

Dosage Forms of Yamatetan

Injection, solution Intravenous

Chemical IUPAC Name

(7S)-7-[[4-(1-amino-3-hydroxy-1,3-dioxopropan-2-ylidene)1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Chemical Formula

C17H17N7O8S4

Cefotetan on Wikipedia

https://en.wikipedia.org/wiki/Cefotetan

Organisms Affected

Enteric bacteria and other eubacteria