Torecan
Torecan - General Information
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Pharmacology of Torecan
Torecan, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, Torecan binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
Torecan for patients
Patients receiving TORECAN (thiethylperazine) should be cautioned about possible combined effects with alcohol and other CNS depressants. Patients should be cautioned not to operate machinery or drive a motor vehicle after ingesting the drug.
Torecan Interactions
Phenothiazines are capable of potentiating CNS depressants (e.g., barbiturates, anesthetics, opiates, alcohol, etc.) as well as atropine and phosphorous insecticides.
Torecan Contraindications
Severe central nervous system (CNS) depression and comatose states. Use of TORECAN (thiethylperazine) is contraindicated in patients who have demonstrated a hypersensitivity reaction (e.g., blood dyscrasias, jaundice) to phenothiazines.
Because severe hypotension has been reported after the intravenous administration of phenothiazines, this route of administration is contraindicated.
Usage in Pregnancy
TORECAN (thiethylperazine) is contraindicated in pregnancy.
Additional information about Torecan
Torecan Indication: For the treatment or relief of nausea and vomiting.
Mechanism Of Action: Torecan is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Torecan's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Torecan does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with thiethylperazine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Thiethylperazine
Synonyms: Ethylthioperazine; Theithylperazine
Drug Category: Anti-emetics
Drug Type: Small Molecule; Approved
Other Brand Names containing Thiethylperazine: Norzine; Torecan;
Absorption: Not Available
Toxicity (Overdose): Manifestations of acute overdosage of TORECAN (thiethylperazine) can be expected to reflect the CNS effects of the drug and include extrapyramidal symptoms (E.P.S), confusion and convulsions with reduced or absent reflexes, respiratory depression and hypotension.
Protein Binding: 60%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Torecan: Tablet Oral
Solution Intramuscular
Chemical IUPAC Name: 2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
Chemical Formula: C22H29N3S2
Thiethylperazine on Wikipedia: https://en.wikipedia.org/wiki/Thiethylperazine
Organisms Affected: Humans and other mammals