Titriplex

Titriplex - General Information

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. [PubChem]

Pharmacology of Titriplex

Edetate calcium is a heavy metal chelating agent. The calcium in edetate calcium can be displaced by divalent or trivalent metals to form a stable water soluble complex that can be excreted in the urine. In theory, 1 g of edetate calcium can theoretically bind 620 mg of lead, but in reality only about 5 mg per gram is actually excreted into the urine in lead poisoned patients. In addition to chelating lead, edetate calcium also chelates and eliminates zinc from the body. Edetate calcium also binds cadmium, copper, iron and manganese, but to a much lesser extent than either lead or zinc. Edetate calcium is relatively ineffective for use in treating mercury, gold or arsenic poisoning.

Titriplex for patients

Titriplex Interactions

There is no known drug interference with standard clinical laboratory tests. Steroids enhance the renal toxicity of edetate calcium disodium in animals. ⁷ Edetate calcium disodium interferes with the action of zinc insulin preparations by chelating the zinc. ⁷

Titriplex Contraindications

Edetate calcium disodium should not be given during periods of anuria, nor to patients with active renal disease or hepatitis.

Additional information about Titriplex

Titriplex Indication: For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.
Mechanism Of Action: The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Edetic Acid
Synonyms: CaEDTA; Calcium Disodium Versenate; Calcium Disodium Edetate (JAN); Calcium disodium versenate (TN); Edetate calcium disodium (USP); EDT; Edetate Calcium; EDTA
Drug Category: Anticoagulants; Chelating Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Edetic Acid: Endrate; Cheladrate; Havidote; Titriplex; Versenate;
Absorption: Poorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection.
Toxicity (Overdose): Inadvertent administration of 5 times the recommended dose, infused intravenously over a 24 hour period, to an asymptomatic 16 month old patient with a blood lead content of 56 mcg/dl did not cause any ill effects. Edetate calcium disodium can aggravate the symptoms of severe lead poisoning, therefore, most toxic effects (cerebral edema, renal tubular necrosis) appear to be associated with lead poisoning. Because of cerebral edema, a therapeutic dose may be lethal to an adult or a pediatric patient with lead encephalopathy. Higher dosage of edetate calcium disodium may produce a more severe zinc deficiency.
Protein Binding: Not Available
Biotransformation: Almost none of the compound is metabolized.
Half Life: The half life of edetate calcium disodium is 20 to 60 minutes.
Dosage Forms of Titriplex: Injection, solution Intravenous drip
Injection, solution Intramuscular
Chemical IUPAC Name: 2-[2-(bis(carboxymethyl)amino)ethyl-(carboxymethyl)amino]acetic acid
Chemical Formula: C10H16N2O8
Edetic Acid on Wikipedia: https://en.wikipedia.org/wiki/EDTA
Organisms Affected: Humans and other mammals