Theocolin

Theocolin - General Information

Theocolin is a cough medicine derived from xanthine and similar to theophylline, that acts as a bronchodilator to open up airways in the lung. It antagonizes adenosine receptors and promotes relaxation of airway smooth muscles. It is also thought to inhibit phosphodiesterases leading to higher levels of cAMP and increased bronchodilation.

Pharmacology of Theocolin

Theocolin is a bronchodilator. Theocolin works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.

Additional information about Theocolin

Theocolin Indication: Used to treat the symptoms of asthma, bronchitis, and emphysema.
Mechanism Of Action: Theocolin is a choline salt of theophylline. Theocolin relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theocolin competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theocolin also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.
Drug Interactions: Aciclovir Aciclovir increases the effect and toxicity of theophylline
Adenosine This xanthine decreases the effect of adenosine
Aprobarbital The barbiturate decreases the effect of theophylline
Amobarbital The barbiturate decreases the effect of theophylline
Butalbital The barbiturate decreases the effect of theophylline
Butabarbital The barbiturate decreases the effect of theophylline
Butethal The barbiturate decreases the effect of theophylline
Dihydroquinidine barbiturate The barbiturate decreases the effect of theophylline
Heptabarbital The barbiturate decreases the effect of theophylline
Hexobarbital The barbiturate decreases the effect of theophylline
Methohexital The barbiturate decreases the effect of theophylline
Methylphenobarbital The barbiturate decreases the effect of theophylline
Pentobarbital The barbiturate decreases the effect of theophylline
Phenobarbital The barbiturate decreases the effect of theophylline
Primidone The barbiturate decreases the effect of theophylline
Quinidine barbiturate The barbiturate decreases the effect of theophylline
Secobarbital The barbiturate decreases the effect of theophylline
Talbutal The barbiturate decreases the effect of theophylline
Zileuton Zileuton increases the effect and toxicity of theophylline
Verapamil Verapamil increases the effect of theophylline
Ticlopidine Ticlopidine increases the effect and toxicity of theophylline
Thiabendazole Thiabendazole increases the effect and toxicity of theophylline
Terbinafine Terbinafine increases the effect and toxicity of theophylline
Tacrine Tacrine increases the effect and toxicity of theophylline
St. John's Wort St. John's Wort decreases the effect of theophylline
Rofecoxib Rofecoxib increases the effect and toxicity of theophylline
Ritonavir Ritonavir decreases the effect of theophylline
Rifampin Rifampin decreases the effect and toxicity of theophylline
Propafenone Propafenone increases the effect of theophylline
Pentoxifylline Pentoxifylline increases the effect and toxicity of theophylline
Mexiletine Mexiletine increases the effect and toxicity of theophylline
Fluvoxamine Fluvoxamine increases the effect and toxicity of theophylline
Halothane Increased risk of cardiac arrhythmia
Isoniazid Isoniazid increases the effect and toxicity of theophylline
Carbamazepine Carbamazepine increases or decreases the effect of theophylline
Cimetidine Cimetidine increases the effect of theophylline
Clarithromycin Clarithromycin increases the effect and toxicity of theophylline
Disulfiram Disulfiram increases the effect and toxicity of theophylline
Atracurium Theophylline decreases the effect of muscle relaxant
Doxacurium Theophylline decreases the effect of muscle relaxant
Lithium Theophylline decreases serum levels of lithium
Metocurine Theophylline decreases the effect of muscle relaxant
Mivacurium Theophylline decreases the effect of muscle relaxant
Pancuronium Theophylline decreases the effect of muscle relaxant
Tubocurarine Theophylline decreases the effect of muscle relaxant
Vecuronium Theophylline decreases the effect of muscle relaxant
Troleandomycin The macrolide increases the effect and toxicity of theophylline
Josamycin The macrolide increases the effect and toxicity of theophylline
Erythromycin The macrolide increases the effect and toxicity of theophylline
Carteolol Antagonism of action and increased effect of theophylline
Nadolol Antagonism of action and increased effect of theophylline
Penbutolol Antagonism of action and increased effect of theophylline
Pindolol Antagonism of action and increased effect of theophylline
Propranolol Antagonism of action and increased effect of theophylline
Sotalol Antagonism of action and increased effect of theophylline
Timolol Antagonism of action and increased effect of theophylline
Peginterferon alfa-2a Interferon increases the effect and toxicity of theophylline
Peginterferon alfa-2b Interferon increases the effect and toxicity of theophylline
Gallamine Triethiodide Theophylline decreases the effect of muscle relaxant
Interferon alfa-2a Interferon increases the effect and toxicity of theophylline
Interferon alfa-2b Interferon increases the effect and toxicity of theophylline
Interferon alfa-n1 Interferon increases the effect and toxicity of theophylline
Ciprofloxacin The quinolone increases the effect of theophylline
Enoxacin The quinolone increases the effect of theophylline
Grepafloxacin The quinolone increases the effect of theophylline
Pefloxacin The quinolone increases the effect of theophylline
Norfloxacin The quinolone increases the effect of theophylline
Mestranol The contraceptive increases the effect and toxicity of theophylline
Ethinyl Estradiol The contraceptive increases the effect and toxicity of theophylline
Ethotoin Decreased effect of both products
Fosphenytoin Decreased effect of both products
Mephenytoin Decreased effect of both products
Phenytoin Decreased effect of both products
Food Interactions: Not Available
Generic Name: Oxtriphylline
Synonyms: Choline theophylline
Drug Category: Bronchodilator Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Oxtriphylline: Choledyl; Theocolin;
Absorption: Not Available
Toxicity (Overdose): Symptoms of toxicity include abdominal pain (continuing or severe), confusion or change in behavior, convulsions (seizures), dark or bloody vomit, diarrhea, dizziness or lightheadedness, fast and/or irregular heartbeat, nervousness or restlessness (continuing), and trembling (continuing).
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Theocolin: Tablet Oral
Elixir Oral
Syrup Oral
Chemical IUPAC Name: 1,3-dimethyl-2-oxopurin-6-olate; 2-hydroxyethyl-trimethylazanium
Chemical Formula: C12H21N5O3
Oxtriphylline on Wikipedia: https://en.wikipedia.org/wiki/Oxtriphylline
Organisms Affected: Humans and other mammals