Sermion

Sermion - General Information

An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. [PubChem]

Pharmacology of Sermion

Sermion is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Sermion also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.

Additional information about Sermion

Sermion Indication: For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
Mechanism Of Action: Sermion acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Sermion is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Nicergoline
Synonyms: Not Available
Drug Category: Nootropic Agents; Vasodilator Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Nicergoline: MNE; Nargoline; Nicergolin [German]; Nicergolina [Dcit]; Nicergoline [Usan-Ban-Inn-Jan]; Nicergolinum [Inn-Latin]; Nicotergoline; Nimergoline; Nimergoline Base; Sermion; Vasospan;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Sermion: Not Available
Chemical IUPAC Name: Not Available
Chemical Formula: C24H26BrN3O3
Nicergoline on Wikipedia: https://en.wikipedia.org/wiki/Nicergoline
Organisms Affected: Humans and other mammals