Plurazol
Plurazol - General Information
Antibacterial, potentially toxic, used to treat certain skin diseases. [PubChem]
Pharmacology of Plurazol
Plurazol is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Plurazol for patients
Plurazol Interactions
Interations
Sulfapyridine may interact with any of the following:
- Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or
- Amiodarone (e.g., Cordarone) or
- Anabolic steroids (nandrolone [e.g., Anabolin], oxandrolone [e.g., Anavar], oxymetholone [e.g., Anadrol], stanozolol [e.g., Winstrol]) or
- Androgens (male hormones) or
- Antithyroid agents (medicine for overactive thyroid) or
- Carbamazepine (e.g., Tegretol) or
- Carmustine (e.g., BiCNU) or
- Chloroquine (e.g., Aralen) or
- Dantrolene (e.g., Dantrium) or
- Daunorubicin (e.g., Cerubidine) or
- Disulfiram (e.g., Antabuse) or
- Divalproex (e.g., Depakote) or
- Estrogens (female hormones) or
- Etretinate (e.g., Tegison) or
- Gold salts (medicine for arthritis) or
- Hydroxychloroquine (e.g., Plaquenil) or
- Mercaptopurine (e.g., Purinethol) or
- Naltrexone (e.g., Trexan) (with long-term, high-dose use) or
- Oral contraceptives (birth control pills) containing estrogen or
- Other anti-infectives by mouth or by injection (medicine for infection) or
- Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g., Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil], perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine [e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine [e.g., Temaril]) or
- Plicamycin (e.g., Mithracin) or
- Valproic acid (e.g., Depakene)�Use of sulfapyridine with these medicines may increase the chance of side effects affecting the liver
- Acetohydroxamic acid (e.g., Lithostat) or
- Dapsone or
- Furazolidone (e.g., Furoxone) or
- Nitrofurantoin (e.g., Furadantin) or
- Primaquine or
- Procainamide (e.g., Pronestyl) or
- Quinidine (e.g., Quinidex) or
- Quinine (e.g., Quinamm) or
- Sulfoxone (e.g., Diasone) or
- Vitamin K (e.g., AquaMEPHYTON, Synkayvite)�Use of sulfapyridine with these medicines may increase the chance of side effects affecting the blood
- Anticoagulants (blood thinners) or
- Ethotoin (e.g., Peganone) or
- Mephenytoin (e.g., Mesantoin)�Use of sulfapyridine with these medicines may increase the chance of side effects of these medicines
- Antidiabetics, oral (diabetes medicine you take by mouth)�Use of oral antidiabetics with sulfapyridine may increase the chance of side effects affecting the blood and/or the side effects or oral antidiabetics
- Methotrexate (e.g., Mexate)�Use of methotrexate with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of methotrexate
- Methyldopa (e.g., Aldomet)�Use of methyldopa with sulfapyridine may increase the chance of side effects affecting the liver and/or the blood
- Phenytoin (e.g., Dilantin)�Use of phenytoin with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of phenytoin
Plurazol Contraindications
Contraindications
Sulfapyridine should not be used if there is an allergy to sulfapyridine, other sulfonamides, furosemide, thiazide diuretics, sulfonylureas, or carbonic anhydrase inhibitors.
Sulfapyridine can cause agranulocytosis, aplastic anemia, or other blood dyscrasias.
Sulfapyridine should not be used when there is other medical problems, especially blood dyscrasias, G6PD deficiency, hepatic function impairment, porphyria, and renal function impairment
Additional information about Plurazol
Plurazol Indication: For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum
Mechanism Of Action: Plurazol is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sulfapyridine
Synonyms: 2-Sulfanilamidopyridin; 2-Sulfanilamidopyridine; 2-Sulfanilylaminopyridine; 2-Sulfapyridine; 4-(2-Pyridinylsulfonyl)aniline; 4-[(2-Pyridylamino)sulfonyl]aniline; N(sup 1)-2-Pyridylsulfanilamide; N(sup1)-Pyridylsulfanilamide; N-2-Pyridylsulfanilamide; N1-2-Pyridylsulfanilamide; Sulphapyridine
Drug Category: Dermatitis herpetiformis suppressant; Dermatologic Agents; Anti-Infectives; Sulfonamides
Drug Type: Small Molecule; Approved
Other Brand Names containing Sulfapyridine: Adiplon; Coccoclase; Dagenan; Eubasin; Eubasinum; Haptocil; M and B 693; Piridazol; Plurazol; Pyriamid; Pyridazol; Relbapiridina; Ronin; Septipulmon; Streptosilpyridine; Sulfidin; Sulfidine; Thioseptal; Trianon;
Absorption: Approximately 60-80%
Toxicity (Overdose): LD50 is 15800 mg/kg (orally in rats).
Protein Binding: Approximately 50% bound to plasma proteins.
Biotransformation: Hepatic.
Half Life: 6-14 hours.
Dosage Forms of Plurazol: Not Available
Chemical IUPAC Name: 4-amino-N-pyridin-2-ylbenzenesulfonamide
Chemical Formula: C11H11N3O2S
Sulfapyridine on Wikipedia: https://en.wikipedia.org/wiki/Sulfapyridine
Organisms Affected: Humans and other mammals
