Osmocaine: Full Drug Profile

Osmocaine - General Information

Osmocaine hydrochloride, also called cyclaine (Merck) or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function.

Pharmacology of Osmocaine

Osmocaine is a local ester-class anesthetic. Local anesthetics produce a transient block of nerve conduction by interfering with sodium channels. This effect of the anesthetic interferes with the development of an action potential across the nerve.

Additional information about Osmocaine

Osmocaine Indication

Used as a local anesthetic for surface application, infiltration or nerve block

Mechanism Of Action

Hexyl caine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel.

Generic Name

Hexylcaine

Drug Category

Anesthetics; Local Anesthetics

Drug Type

Small Molecule; Approved

Other Brand Names containing Hexylcaine

Cyclaine; Hexilcaina [INN-Spanish]; Hexylcaine hydrochloride; Hexylcainum [INN-Latin]; Osmocaine;

Toxicity (Overdose)

Symptoms of anesthetic overdose include headache, tinnitus, circumoral and tongue paresthesias, restlessness, talkativeness, facial twitching, convulsions, respiratory arrest, and cardiac depression

Biotransformation

Hydrolyzed by plasma esterases to benzoic acid and other derivatives

Half Life

<10 minutes

Chemical IUPAC Name

1-(cyclohexylamino)propan-2-yl benzoate

Chemical Formula

C16H23NO2

Hexylcaine on Wikipedia

https://en.wikipedia.org/wiki/Hexylcaine

Organisms Affected

Humans and other mammals