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Normiflo: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Normiflo - General Information

Normiflo (brand name Normiflo) is an anticoagulant. It is used for prevention of deep vein thrombosis. [Wikipedia]

 

Pharmacology of Normiflo

Normiflo, an anticoagulant, is a fractionated heparin. It acts at multiple sites in the normal coagulation system to inhibit reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo.

 

Normiflo for patients

Tell your doctor your medical history, especially of: liver problems, kidney problems, heart disease, eye problems, bleeding problems, blood disorders, stomach/intestinal problems, severe high blood pressure, stroke, eye/brain/spinal cord surgery, allergies (especially to drugs or pork). This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is unknown if this drug is excreted into breast milk. Consult your doctor before breast-feeding.

 

Normiflo Interactions

Anticoagulants including coumarin derivatives, indandione derivatives, and platelet aggregation inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs), and aspirin may increase the risk of bleeding when administered concomitantly with ardeparin.

 

Normiflo Contraindications

Contraindicated in active bleeding (can exacerbate bleeding), hypertension (can increase the risk of cerebral hemorrhage), and hemorrhagic stroke (can increase the risk of uncontrollable hemorrhage).

 

Additional information about Normiflo

Normiflo Indication: For prevention of deep vein thrombosis, which may result in pulmonary embolism, following knee surgery. Mechanism Of Action: Normiflo binds to antithrombin III, accelerating its activity and inactivating factor Xa and thrombin, thereby inhibiting thrombosis. Normiflo also binds to heparin cofactor II, inhibiting thrombin. Normiflo does not effect prothrombin time (PT) assays and may prolong activated partial thromboplastin time (APTT). Normiflo has double the anti-factor Xa activity of anti-factor IIa activity, compared to unfractionated heparin which has approximately equal anti-factor Xa activity and anti-factor IIa activity. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Ardeparin Synonyms: Not Available Drug Category: Anticoagulants; Fibrinolytic Agents Drug Type: Small Molecule; Approved Other Brand Names containing Ardeparin: Normiflo; Absorption: Well absorbed following subcutaneous administration, with a mean bioavailability of 92% (based on anti-factor Xa activity). Toxicity (Overdose): Symptoms of overdose may include excessive bleeding and bruising. Protein Binding: Not Available Biotransformation: Liver and the reticulo-endothelial system are the sites of biotransformation. Half Life: Elimination half-life for anti-factor Xa activity averages 3.3 hours following a single intravenous dose, while elimination half-life for anti-factor IIa activity averages 1.2 hours following a single intravenous dose. Dosage Forms of Normiflo: Solution IntravenousLiquid IrrigationSolution SubcutaneousLiquid IntravenousSolution Intraperitoneal Chemical IUPAC Name: 6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-3-[5-(6-carboxy-4,5-dihydroxy-3-sulfooxyoxan-2-yl)oxy-6-(hydroxymethyl)-3-(sulfoamino)-4-sulfooxyoxan-2-yl]oxy-4-hydroxy-5-sulfooxyoxane-2-carboxylic acid Chemical Formula: C26H42N2O37S5 Ardeparin on Wikipedia: https://en.wikipedia.org/wiki/Ardeparin Organisms Affected: Humans and other mammals