Normiflo
Normiflo - General Information
Normiflo (brand name Normiflo) is an anticoagulant. It is used for prevention of deep vein thrombosis. [Wikipedia]
Pharmacology of Normiflo
Normiflo, an anticoagulant, is a fractionated heparin. It acts at multiple sites in the normal coagulation system to inhibit reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo.
Normiflo for patients
Tell your doctor your medical history, especially of: liver problems, kidney problems, heart disease, eye problems, bleeding problems, blood disorders, stomach/intestinal problems, severe high blood pressure, stroke, eye/brain/spinal cord surgery, allergies (especially to drugs or pork). This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is unknown if this drug is excreted into breast milk. Consult your doctor before breast-feeding.
Normiflo Interactions
Anticoagulants including coumarin derivatives, indandione derivatives, and platelet aggregation inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs), and aspirin may increase the risk of bleeding when administered concomitantly with ardeparin.
Normiflo Contraindications
Contraindicated in active bleeding (can exacerbate bleeding), hypertension (can increase the risk of cerebral hemorrhage), and hemorrhagic stroke (can increase the risk of uncontrollable hemorrhage).
Additional information about Normiflo
Normiflo Indication: For prevention of deep vein thrombosis, which may result in pulmonary embolism, following knee surgery.
Mechanism Of Action: Normiflo binds to antithrombin III, accelerating its activity and inactivating factor Xa and thrombin, thereby inhibiting thrombosis. Normiflo also binds to heparin cofactor II, inhibiting thrombin. Normiflo does not effect prothrombin time (PT) assays and may prolong activated partial thromboplastin time (APTT). Normiflo has double the anti-factor Xa activity of anti-factor IIa activity, compared to unfractionated heparin which has approximately equal anti-factor Xa activity and anti-factor IIa activity.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Ardeparin
Synonyms: Not Available
Drug Category: Anticoagulants; Fibrinolytic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Ardeparin: Normiflo;
Absorption: Well absorbed following subcutaneous administration, with a mean bioavailability of 92% (based on anti-factor Xa activity).
Toxicity (Overdose): Symptoms of overdose may include excessive bleeding and bruising.
Protein Binding: Not Available
Biotransformation: Liver and the reticulo-endothelial system are the sites of biotransformation.
Half Life: Elimination half-life for anti-factor Xa activity averages 3.3 hours following a single intravenous dose, while elimination half-life for anti-factor IIa activity averages 1.2 hours following a single intravenous dose.
Dosage Forms of Normiflo: Solution Intravenous
Liquid Irrigation
Solution Subcutaneous
Liquid Intravenous
Solution Intraperitoneal
Chemical IUPAC Name: 6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-3-[5-(6-carboxy-4,5-dihydroxy-3-sulfooxyoxan-2-yl)oxy-6-(hydroxymethyl)-3-(sulfoamino)-4-sulfooxyoxan-2-yl]oxy-4-hydroxy-5-sulfooxyoxane-2-carboxylic acid
Chemical Formula: C26H42N2O37S5
Ardeparin on Wikipedia: https://en.wikipedia.org/wiki/Ardeparin
Organisms Affected: Humans and other mammals
