Nolahist: Full Drug Profile

Nolahist - General Information

Nolahist is an antihistamine. Nolahist blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. It is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.
Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.

Pharmacology of Nolahist

Nolahist is an antihistamine. Nolahist blocks the effects of the naturally occurring chemical histamine in your body.

Nolahist for patients

1. Products containing antihistamines may cause drowsiness.
2. Patients should not engage in activities requiring mental alertness, such as driving or operating machinery or appliances.
3. Alcohol or other sedative drugs may enhance the drowsiness caused by antihistamines.
4. Patients should not take Phenindamine Tablets if they are receiving a monoamine oxidase inhibitor or within 2 weeks of stopping such treatment.
5. This medication should not be given to children less than 12 years of age.

Nolahist Interactions

Nolahist Contraindications

Antihistamines should not be used to treat lower respiratory tract symptoms, including asthma. This product is contraindicated in patients with narrow-angle glaucoma or urinary retention, and in patients receiving monoamine oxidase (MAO) inhibitor therapy or within 2 weeks of stopping such treatment. It is also contraindicated in patients with severe hypertension, severe coronary artery disease, hyperthyroidism, and in those who have shown hypersensitivity or idiosyncrasy to its components, to adrenergic agents, or to other drugs of similar chemical structures. Manifestations of patient idiosyncrasy to adrenergic agents include: insomnia, dizziness, weakness, tremor, or arrhythmias.

Additional information about Nolahist

Nolahist Indication

Used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold.

Mechanism Of Action

Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.

Food Interactions

Take with food to reduce irritation.

Generic Name

Phenindamine

Synonyms

Fenindamina [inn-spanish]; Phenindaminum [inn-latin]; Phenindiamine

Drug Category

Antihistamines; Histamine H1 Antagonists

Drug Type

Small Molecule; Approved

Other Brand Names containing Phenindamine

Nolahist; Thephorin;

Toxicity (Overdose)

Symptoms of a phenindamine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.

Chemical IUPAC Name

2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,3-c]pyridine

Chemical Formula

C19H19N

Organisms Affected

Humans and other mammals