Metaplexan: Full Drug Profile
Metaplexan - General Information
Metaplexan is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Pharmacology of Metaplexan
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Metaplexan is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Metaplexan for patients
Metaplexan Interactions
Mequitazine can interact with CNS depressant, antichlolinergic, TCA, MAOIs, and alcohol.
Metaplexan Contraindications
Prostatic adenoma Closed Angle Glaucoma Paralytic ileus Stenosis of the pylore Myasthenia Gravis Status Asthmaticus Obstructive chronic broncho-pneumopath Hypersensitivity to the Phenothiazines concomitant MAOI therapy Alcohol Additional information about Metaplexan Metaplexan Indication: For the treatment of Hay fever, urticaria (hives) and allergic rhinitis Mechanism Of Action: Metaplexan binds to the histamine H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Mequitazine Synonyms: Mequitazina [Inn-Spanish]; Mequitazina [Spanish]; Mequitazinum [Inn-Latin] Drug Category: Bronchodilator Agents; Histamine H1 Antagonists Drug Type: Small Molecule; Approved Other Brand Names containing Mequitazine: Butix; Instotal; Kitazemin; Metaplexan; Mircol; Primalan; Vigigan; Virginan; Zesulan; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Metaplexan: Not Available Chemical IUPAC Name: 10-(1-azabicyclo[2.2.2]octan-8-ylmethyl)phenothiazine Chemical Formula: C20H22N2S Mequitazine on Wikipedia: https://en.wikipedia.org/wiki/Mequitazine Organisms Affected: Humans and other mammals