Marazine - General Information

A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)


Pharmacology of Marazine

Marazine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent. Marazine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which cyclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects.


Marazine for patients


Marazine Interactions


Marazine Contraindications

Cyclizine is contra-indicated in individuals who have previously reacted adversely to cyclizine.


Additional information about Marazine

Marazine Indication: For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems).
Mechanism Of Action: Vomiting (emesis) is essentially a protective mechanism for removing irritant or otherwise harmful substances from the upper GI tract. Emesis or vomiting is controlled by the vomiting centre in the medulla region of the brain, an important part of which is the chemotrigger zone (CTZ). The vomiting centre possesses neurons which are rich in muscarinic cholinergic and histamine containing synapses. These types of neurons are especially involved in transmission from the vestibular apparatus to the vomiting centre. Motion sickness principally involves overstimulation of these pathways due to various sensory stimuli. Hence the action of cyclizine which acts to block the histamine receptors in the vomiting centre and thus reduce activity along these pathways. Furthermore since cyclizine possesses anti-cholinergic properties as well, the muscarinic receptors are similarly blocked.
Drug Interactions: Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Rivastigmine Possible antagonism of action
Food Interactions: Take without regard to meals.
Food may reduce irritation.
Avoid alcohol.
Generic Name: Cyclizine
Synonyms: Ciclizina [Inn-Spanish]; Cyclizine Chloride; Cyclizine Hydrochloride; Cyclizinum [Inn-Latin]
Drug Category: Antiemetics; Piperazine Derivatives
Drug Type: Small Molecule; Approved

Other Brand Names containing Cyclizine: Emoquil; Marazine; Marezine; Marezine Hydrochloride; Marzine; Nautazine; Ne-Devomit; Neo-Devomit; Reis-Fit; Valoid; Wellcome;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Cyclizine is metabolised to its N-demethylated derivative, norcyclizine, which has little antihistaminic (H1) activity compared to Cyclizine.
Half Life: 20 hours
Dosage Forms of Marazine: Tablet Oral
Solution Intravenous
Solution Intramuscular
Chemical IUPAC Name: 1-[di(phenyl)methyl]-4-methylpiperazine
Chemical Formula: C18H22N2
Cyclizine on Wikipedia:
Organisms Affected: Humans and other mammals