LithoTab

LithoTab - General Information

LithoTab was used during the 19th century to treat gout. LithoTab salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. LithoTab can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.

Pharmacology of LithoTab

Not Available

Additional information about LithoTab

LithoTab Indication: Not Available
Mechanism Of Action: The precise mechanism of action of Li+ as a mood-stabilizing agent is currently unknown. It is possible that Li+ produces its effects by interacting with the transport of monovalent or divalent cations in neurons. An increasing number of scientists have come to the conclusion that the excitatory neurotransmitter glutamate is the key factor in understanding how lithium works. LithoTab has been shown to change the inward and outward currents of glutamate receptors (especially GluR3), without a shift in reversal potential. LithoTab has been found to exert a dual effect on glutamate receptors, acting to keep the amount of glutamate active between cells at a stable, healthy level, neither too much nor too little. It is postulated that too much glutamate in the space between neurons causes mania, and too little, depression. Another mechanism by which lithium might help to regulate mood include the non-competitive inhibition of an enzyme called inositol monophosphatase. Alternately lithium's action may be enhanced through the deactivation of the GSK-3B enzyme. The regulation of GSK-3B by lithium may affect the circadian clock. GSK-3 is known for phosphorylating and thus inactivating glycogen synthase. GSK-3B has also been implicated in the control of cellular response to damaged DNA.
Drug Interactions: Aminophylline Theophylline decreases serum levels of lithium
Benazepril The ACE inhibitor increases serum levels of lithium
Bendroflumethiazide The thiazide diuretic increases serum levels of lithium
Benzthiazide The thiazide diuretic increases serum levels of lithium
Chlorothiazide The thiazide diuretic increases serum levels of lithium
Chlorthalidone The thiazide diuretic increases serum levels of lithium
Cyclothiazide The thiazide diuretic increases serum levels of lithium
Hydrochlorothiazide The thiazide diuretic increases serum levels of lithium
Hydroflumethiazide The thiazide diuretic increases serum levels of lithium
Indapamide The thiazide diuretic increases serum levels of lithium
Methyclothiazide The thiazide diuretic increases serum levels of lithium
Metolazone The thiazide diuretic increases serum levels of lithium
Polythiazide The thiazide diuretic increases serum levels of lithium
Quinethazone The thiazide diuretic increases serum levels of lithium
Trichlormethiazide The thiazide diuretic increases serum levels of lithium
Verapamil Signs of lithium toxicity
Bromfenac The NSAID increases serum levels of lithium
Caffeine Caffeine decreases serum levels of lithium
Diclofenac The NSAID increases serum levels of lithium
Eplerenone Eplerenone increases serum levels of lithium
Etoricoxib Etoricoxib increases serum levels of lithium
Ibuprofen The NSAID increases serum levels of lithium
Indomethacin The NSAID increases serum levels of lithium
Ketorolac The NSAID increases serum levels of lithium
Losartan Losartan increases serum levels of lithium
Mefenamic acid The NSAID increases serum levels of lithium
Meloxicam Meloxicam increases serum levels of lithium
Methyldopa Signs of increased lithium without increase with this combination
Metronidazole Metronidazole increases the effect and toxicity of lithium
Naproxen The NSAID increases serum levels of lithium
Phenylbutazone The NSAID increases serum levels of lithium
Piroxicam The NSAID increases serum levels of lithium
Topiramate Topiramate could modify lithium levels
Candesartan The ARB increases serum levels of lithium
Eprosartan The ARB increases serum levels of lithium
Forasartan The ARB increases serum levels of lithium
Irbesartan The ARB increases serum levels of lithium
Saprisartan The ARB increases serum levels of lithium
Tasosartan The ARB increases serum levels of lithium
Telmisartan The ARB increases serum levels of lithium
Valsartan The ARB increases serum levels of lithium
Captopril The ACE inhibitor increases serum levels of lithium
Cilazapril The ACE inhibitor increases serum levels of lithium
Enalapril The ACE inhibitor increases serum levels of lithium
Fosinopril The ACE inhibitor increases serum levels of lithium
Lisinopril The ACE inhibitor increases serum levels of lithium
Moexipril The ACE inhibitor increases serum levels of lithium
Perindopril The ACE inhibitor increases serum levels of lithium
Quinapril The ACE inhibitor increases serum levels of lithium
Ramipril The ACE inhibitor increases serum levels of lithium
Spirapril The ACE inhibitor increases serum levels of lithium
Trandolapril The ACE inhibitor increases serum levels of lithium
Celecoxib The COX-2 inhibitor increases serum levels of lithium
Lumiracoxib The COX-2 inhibitor increases serum levels of lithium
Rofecoxib The COX-2 inhibitor increases serum levels of lithium
Valdecoxib The COX-2 inhibitor increases serum levels of lithium
Citric Acid The urine alkalizer decreases the effect of lithium
Haloperidol Possible extrapyramidal effects and neurotoxicity with this combination
Potassium The urine alkalizer decreases the effect of lithium
Sodium bicarbonate The urine alkalizer decreases the effect of lithium
Dyphylline Theophylline decreases serum levels of lithium
Theophylline Theophylline decreases serum levels of lithium
Oxtriphylline Theophylline decreases serum levels of lithium
Fluoxetine The SSRI increases serum levels of lithium
Fluvoxamine The SSRI increases serum levels of lithium
Iodine Possible hypothyroidism with this combination
Sumatriptan Possible serotoninergic syndrome with this combination
Sibutramine Possible serotoninergic syndrome with this combination
Food Interactions: Avoid alcohol.
Take with food to reduce irritation. Drink plenty of liquids.
Do not change your salt intake from day to day without telling your doctor.
Avoid excessive quantities of coffee or tea (Caffeine).
Avoid iodine supplements.
Generic Name: Lithium
Synonyms: Not Available
Drug Category: Not Available
Drug Type: Small Molecule; Approved

Other Brand Names containing Lithium: LithoTab; Eskalith;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of LithoTab: Tablet, extended release Oral
Liquid Oral
Capsule Oral
Syrup Oral
Chemical IUPAC Name: lithium(+1) cation
Chemical Formula: Li+
Lithium on Wikipedia: https://en.wikipedia.org/wiki/Lithium
Organisms Affected: Not Available