Kantrex
Kantrex - General Information
An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis. [PubChem]
Pharmacology of Kantrex
Kantrex is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Additional information about Kantrex
Kantrex Indication: For the treatment of Tuberculosis
Mechanism Of Action: Aminoglycosides like Kantrex "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Kantrex binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Streptomycin
Synonyms: Streptomycin Sesquisulfate Hydrate; Streptomycin a Sulfate; Streptomycin Sulfate; Streptomycin Sulphate; Streptomycin, Sulfate Salt
Drug Category: Anti-Bacterial Agents; Aminoglycosides
Drug Type: Small Molecule; Approved
Other Brand Names containing Streptomycin: Kantrex;
Absorption: Not Available
Toxicity (Overdose): LD50=430 mg/kg (Orally in rats with Streptomycin Sulfate); Side effect include nausea, vomiting, and vertigo, paresthesia of face, rash, fever, urticaria, angioneurotic edema, and eosinophilia.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Kantrex: Powder, for solution Intramuscular
Chemical IUPAC Name: 2-[(1S,2R,3R,4S,5R,6R)-5-(diaminomethylideneamino)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylaminooxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine
Chemical Formula: C21H39N7O12
Streptomycin on Wikipedia: https://en.wikipedia.org/wiki/Streptomycin
Organisms Affected: Enteric bacteria and other eubacteria
