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Hydromox: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Hydromox - General Information

Hydromox (INN, brand name Hydromox) is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.

 

Pharmacology of Hydromox

Hydromox is a thiazide diuretic used to treat hypertension. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

 

Additional information about Hydromox

Hydromox Indication: Used to treat hypertension. Mechanism Of Action: As a diuretic, quinethazone inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like quinethazone also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of quinethazone is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. Drug Interactions: Not Available Food Interactions: Take with food to increase bioavailability. Generic Name: Quinethazone Synonyms: Chinetazone [dcit]; Chinethazonum; Quinetazona [inn-spanish]; Quinethazon; Quinethazonum [inn-latin] Drug Category: Antihypertensive Agents; Diuretics, Thiazide Drug Type: Small Molecule; Approved Other Brand Names containing Quinethazone: Aquamox; Hydromox; Idrokin; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Hydromox: Tablet Oral Chemical IUPAC Name: 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide Chemical Formula: C10H12ClN3O3S Quinethazone on Wikipedia: https://en.wikipedia.org/wiki/Quinethazone Organisms Affected: Humans and other mammals