Protamine
- Generic Name: protamines
- Brand Name: Protamine
Protamine (Protamines) side effects drug center
Protamine Side Effects Center
What Is Protamine?
Protamine Sulfate (protamines) is a heparin antagonist and a weak anticoagulant indicated in the treatment of heparin (a drug used to treat and prevent blood clots) overdose.
What Are Side Effects of Protamine?
Common side effects of Protamine Sulfate include:
- sudden fall in blood pressure,
- slow heart rate (bradycardia),
- pulmonary hypertension,
- shortness of breath, or
- temporary flushing and a feeling of warmth.
There have been reports of severe allergic reaction (anaphylaxis) after using Protamine Sulfate that resulted in respiratory difficulty, systemic high blood pressure (hypertension), nausea, vomiting, fatigue, and back pain.
Dosage for Protamine
Protamine Sulfate is administered by a doctor and is given by very slow intravenous (IV) injection in doses not to exceed 50 mg in any 10-minute period.
What Drugs, Substances, or Supplements Interact with Protamine?
Protamine sulfate may interact with certain antibiotics, including several of the cephalosporins and penicillins. Tell your doctor all medications you are taking.
Protamine During Pregnancy or Breastfeeding
Protamine sulfate should be given to a pregnant woman only if prescribed. It is not known whether this drug passes into breast milk. Consult a doctor before breastfeeding.
Additional Information
Our Protamine Sulfate (protamines) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Protamine Professional Information
SIDE EFFECTS
Intravenous injections of protamine (protamines) may cause a sudden fall in blood pressure, bradycardia, pulmonary hypertension, dyspnea, or transitory flushing and a feeling of warmth. There have been reports of anaphylaxis that resulted in respiratory embarrassment (see PRECAUTIONS).Other reported adverse reactions include systemic hypertension, nausea, vomiting and lassitude. Back pain has been reported rarely in conscious patients undergoing such procedures as cardiac catheterization. Because fatal reactions often resembling anaphylaxis have been reported after administration of protamine sulfate (protamine (protamines) s) , the drug should be given only when resuscitation techniques and treatment of anaphylactoid shock are readily available.
Read the entire FDA prescribing information for Protamine (Protamines)
&Copy; Protamine Patient Information is supplied by Cerner Multum, Inc. and Protamine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.