Midamor
- Generic Name: amiloride
- Brand Name: Midamor
Midamor (Amiloride) side effects drug center
Midamor Side Effects Center
Midamor (amiloride HCl) is an antikaliuretic diuretic agent indicated as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension. Midamor is no longer available in the U.S. Generic versions may still be available. Side effects of Miamor (amiloride HCl) include numbness or tingly feeling, muscle pain or weakness, slow, fast, or uneven heartbeat, headache, nausea, loss of appetite, stomach pain, gas, or skin rash. Serious side effects include high blood potassium (hyperkalemia).
Midamor was available in 5 mg tablets. Midamor should be administered with food. One 5 mg tablet daily, should be added to the usual antihypertensive or diuretic dosage of a kaliuretic diuretic. The dosage may be increased to 10 mg per day if necessary. Midamor may interact with cyclosporine, tacrolimus, lithium, ACE inhibitors, or indomethacin or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use. There are no adequate and well-controlled studies in pregnant women or pediatric patients. The drug should be used during pregnancy only if clearly needed. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Our Miamor (amiloride HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Midamor Consumer Information
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop taking amiloride and call your doctor at once if you have:
- increased thirst, decreased urination;
- heavy sweating, or hot and dry skin;
- tremors, confusion, loss of consciousness;
- jaundice (yellowing of the skin or eyes);
- high potassium--tiredness, numbness or tingling, slow or unusual heart rate, muscle weakness or limp feeling; or
- low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Common side effects may include:
- nausea, stomach pain, gas, loss of appetite;
- headache; or
- rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Midamor (Amiloride)
Midamor Professional Information
SIDE EFFECTS
MIDAMOR (amiloride) is usually well tolerated and except for hyperkalemia (serum potassium levels greater than 5.5 mEq per liter † see BOXED WARNING), significant adverse effects have been reported infrequently. Minor adverse reactions were reported relatively frequently (about 20%) but the relationship of many of the reports to amiloride HCl is uncertain and the overall frequency was similar in hydrochlorothiazide treated groups. Nausea/anorexia, abdominal pain, flatulence, and mild skin rash have been reported and probably are related to amiloride. Other adverse experiences that have been reported with amiloride are generally those known to be associated with diuresis, or with the underlying disease being treated.
The adverse reactions for MIDAMOR (amiloride) listed in the following table have been arranged into two groups: (1) incidence greater than one percent; and (2) incidence one percent or less. The incidence for group (1) was determined from clinical studies conducted in the United States (837 patients treated with MIDAMOR (amiloride) ). The adverse effects listed in group (2) include reports from the same clinical studies and voluntary reports since marketing. The probability of a causal relationship exists between MIDAMOR (amiloride) and these adverse reactions, some of which have been reported only rarely.
| Incidence >1% | Incidence ≤ 1% |
| Body as a Whole | |
|
Headache** Weakness Fatigability |
Back pain Chest pain Neck/shoulder ache Pain, extremities |
| Cardiovascular | |
| None |
Angina pectoris Orthostatic hypotension Arrhythmia Palpitation |
| Digestive | |
|
Nausea/anorexia** Diarrhea** Vomiting** Abdominal pain Gas pain Appetite changes Constipation |
Jaundice GI bleeding Abdominal fullness GI disturbance Thirst Heartburn Flatulence Dyspepsia |
| Metabolic | |
| Elevated serum potassium levels (> 5.5 mEq per Liter)*** | None |
| Skin | |
| None |
Skin rash Itching Dryness of mouth Pruritus Alopecia |
| Musculoskeletal | |
| Muscle cramps |
Joint pain Leg ache |
| Nervous | |
|
Dizziness Encephalopathy |
Paresthesia Tremors Vertigo |
| Psychiatric | |
| None |
Nervousness Mental confusion Insomnia Decreased libido Depression Somnolence |
| Respiratory | |
|
Cough Dyspnea | Shortness of breath |
| Special Senses | |
| None |
Visual disturbances Nasal congestion Tinnitus Increased intraocular pressure |
| Urogenital | |
| Impotence |
Polyuria Dysuria Urinary frequency Bladder spasms Gynecomastia |
** Reactions occurring in 3% to 8% of patients treated with MIDAMOR (amiloride) . (Those reactions occurring in less than 3% of the patients are unmarked.)
*** See BOXED WARNING.
Causal Relationship Unknown: Other reactions have been reported but occurred under circumstances where a causal relationship could not be established. However, in these rarely reported events, that possibility cannot be excluded. Therefore, these observations are listed to serve as alerting information to physicians.
- Activation of probable pre-existing peptic ulcer
- Aplastic anemia
- Neutropenia
- Abnormal liver function
Read the entire FDA prescribing information for Midamor (Amiloride)
&Copy; Midamor Patient Information is supplied by Cerner Multum, Inc. and Midamor Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.