Magnesium (antidote)

Magnesium (antidote) is used to treat digitalis toxicity and hydrofluoric acid burns in adults and hypomagnesemia or torsades de pointes in pediatric patients.

• Magnesium (antidote) is available under the following different brand names: N/A

Dosages of Magnesium (Antidote):

Dosage Forms and Strengths

IV infusion, premixed in D5W

• 10mg/mL
• 20mg/mL

IV infusion, premixed in water

• 40mg/mL
• 80mg/mL

Injection for dilution

• 500mg/mL

Dosage Considerations – Should be Given as Follows:

Digitalis Toxicity

• 1-2 g intravenous push (IVP) over 5 minutes, then 1 g/hour drip (if Digibind not available)
• Monitor levels every 2 hours; therapeutic goal is 4.5 mEq/L

Other Indications and Uses

• Hydrofluoric acid burns

Pediatric: Hypomagnesemia or Torsades de Pointes

• Indicated for the treatment of documented hypomagnesemia or for torsades de pointes (polymorphic VT associated with long QT interval)
• There is insufficient evidence to recommend for or against the routine administration of magnesium during cardiac arrest
• 25-50 mg/kg intravenous/intraosseus (IV/IO) over 10-20 minutes (may infuse faster in torsades de pointes); not to exceed 2 g/dose
• Kleinman ME, et al. Circ 2010 Nov;122(18):S876-S908

Side effects of magnesium (antidote) include:

• Flushing
• Low blood pressure (hypotension)
• Hypothermia
• CNS depression
• Motor and respiratory paralysis
• Abnormal ECG
• Diarrhea
• Heart block
• Prolonged bleeding time

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

• Magnesium (antidote) has no listed severe interactions with other drugs.
• Magnesium (antidote) has no listed serious interactions with other drugs.
• Magnesium (antidote) has no listed moderate interactions with other drugs.
• Magnesium (antidote) has no listed mild interactions with other drugs.
   

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

• This medication contains magnesium (antidote). Do not take magnesium (antidote) if you are allergic to magnesium (antidote) or any ingredients contained in this drug.
• Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• Hypersensitivity
• Heart block
• Heart disease

Effects of Drug Abuse

No information available

Short-Term Effects

See "What Are Side Effects Associated with Using Magnesium (Antidote)?”

Long-Term Effects

See "What Are Side Effects Associated with Using Magnesium (Antidote)?”

Cautions

• Caution in myasthenia gravis or another neuromuscular disease
• Caution in renal impairment
• Serum levels poorly correlate to body stores

Pregnancy and Lactation

• Magnesium (antidote) is generally acceptable for use during pregnancy. Controlled studies in pregnant women show no evidence of fetal risk.
• Magnesium (antidote) is safe for use while breastfeeding.