Actonel vs. Prolia

• Are Actonel and Prolia the Same Thing?
• What Are Possible Side Effects of Actonel?
• What Are Possible Side Effects of Prolia?
• What is Actonel?
• What is Prolia?
• What Drugs Interact with Actonel?
• What Drugs Interact with Prolia?
• How Should Actonel Be Taken?
• How Should Prolia Be Taken?

Prolia (denosumab) and Actonel (risedronate sodium) are used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.

Actonel is also used to treat or prevent osteoporosis in men, and to treat Paget's disease of bone.

Prolia and Actonel belong to different drug classes. Prolia is a monoclonal antibody and Actonel is a bisphosphonate.

Common side effects of Actonel include:

• upset stomach
• stomach pain
• headache
• flu symptoms
• muscle pain
• diarrhea, constipation, or
• joint or back pain

Common side effects of Prolia include:

• low calcium levels (especially if you have kidney problems),
• weakness,
• constipation,
• back pain,
• muscle pain,
• pain in your arms and legs,
• anemia,
• diarrhea, or
• skin problems (eczema, blisters, dry skin, peeling, redness, itching, small bumps).

You may also be more likely to get a serious infection, such as a skin, ear, stomach/gut, or bladder infection while taking Prolia. Tell your doctor if you develop signs of infection, such as:

• fever/chills, night sweats,
• red/swollen/tender/warm skin (with or without pus),
• severe stomach or abdominal pain,
• ear pain or drainage, trouble hearing,
• frequent/painful/burning urination, or
• pink/bloody urine.
• severe itching, burning, rask, blistering, peeling, or dryness of the skin,
• cough,
• shortness of breath,
• pinpoint purple or red spots under your skin,
• flu symptoms, or
• weight loss.

Tell your doctor if your experience serious side effects of Prolia including jaw pain, new or unusual thigh/hip/groin pain, or bone/joint/muscle pain.

Actonel (risedronate sodium) is a bisphosphonate used to treat or prevent osteoporosis in men and women, and is also used to treat Paget's disease of bone.

Prolia (denosumab) is a monoclonal antibody used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.

 

Actonel may interact with aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs).

Prolia may interact with steroids or cancer medicine, cyclosporine, sirolimus, tacrolimus, basiliximab, muromonab-CD3, mycophenolate mofetil, azathioprine, leflunomide, or etanercept.

 

Dosage of Actonel depends on the condition being treated.

Prolia should be administered by a doctor. The recommended dose of Prolia is 60 mg administered as a single subcutaneous (under the skin) injection once every 6 months.