Nayzilam vs. Lamictal

Nayzilam (midazolam) Nasal Spray and Lamictal (lamotrigine) are used to treat seizures.

Nayzilam is specifically used for acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 12 years of age and older.

Nayzilam and Lamictal belong to different drug classes. Nayzilam is a benzodiazepine and Lamictal is an anticonvulsant.

Side effects of Nayzilam and Lamictal that are similar include drowsiness, headache, throat irritation/sore throat, and runny nose.

Side effects of Nayzilam that are different from Lamictal include nasal discomfort.

Side effects of Lamictal that are different from Nayzilam include dizziness, shaking (tremors), sleepiness, tired feeling, loss of coordination, double vision, blurred vision, nausea, vomiting, upset stomach, stomach pain, dry mouth, changes in menstrual periods, back pain, and sleep problems (insomnia).

Nayzilam may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol), ketoconazole, itraconazole, and clarithromycin.

Lamictal may interact with other seizure medications and olanzapine.

Withdrawal symptoms may occur if you suddenly stop taking Nayzilam.

Common side effects of Nayzilam include:

• drowsiness,
• headache,
• nasal discomfort,
• throat irritation, and
• runny nose

Common side effects of Lamictal include:

• dizziness,
• shaking (tremors),
• sleepiness,
• tired feeling,
• drowsiness,
• loss of coordination,
• headache,
• double vision,
• blurred vision,
• nausea,
• vomiting,
• upset stomach,
• stomach pain,
• dry mouth,
• changes in menstrual periods,
• back pain,
• sore throat,
• runny nose, or
• sleep problems (insomnia).

Serious side effects of Lamictal you should report to your doctor include:

• rash,
• worsening depression or suicidal thoughts, and
• flu-like symptoms such as body aches or swollen glands.

Nayzilam (midazolam) is a benzodiazepine indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient's usual seizure pattern in patients with epilepsy 12 years of age and older.

Lamictal (lamotrigine) is an anticonvulsant used alone or in combination with other antiseizure medications for treating certain types of seizures.

Nayzilam may interact with other drugs that can make you sleepy (other benzodiazepines and sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, opioids, alcohol), ketoconazole, itraconazole, and clarithromycin. Tell your doctor all medications and supplements you use.

Lamictal may interact with carbamazepine, phenytoin, phenobarbital, primidone, or rifampin.

Lamictal may also interact with hormonal forms of birth control (pills, injections, implants, or skin patches), divalproex, oxcarbazepine, or valproic acid.

The initial dose of Nayzilam is one spray (5 mg dose) administered into one nostril. A second dose of one additional spray (5 mg dose) Nayzilam may be administered into the opposite nostril after 10 minutes if the patient has not responded to the initial dose.

Lamictal doses depend on the condition being treated and on whether it is used alone or in combination with other antiseizure medications.