Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.

Fludrocortisone vs. Hydrocortisone: Comparison

Medically reviewed by Min Clinic Staff | Updated: January 2026

Are Fludrocortisone and Hydrocortisone the Same Thing?

Fludrocortisone acetate tablets and hydrocortisone cream are corticosteroids used to treat different conditions.

Fludrocortisone is used as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.

Hydrocortisone cream is a topical (for the skin) medication used to treat inflammation of the skin caused by a number of conditions such as allergic reactions, eczema, or psoriasis.

What Are Possible Side Effects of Fludrocortisone?

Common side effects of Fludrocortisone include: