Xenleta vs. Ceftin, Omnicef

Xenleta (lefamulin) and Ceftin, Omnicef (cefuroxime) are used to treat bacterial pneumonia.

Ceftin, Omnicef is also used to treat infections with susceptible bacteria including skin and middle ear infections, tonsillitis, throat infections, laryngitis, bronchitis, urinary tract infections (UTIs), and gonorrhea.

Xenleta and Ceftin, Omnicef are different types of antibiotics. Xenleta is a pleuromutilin antibacterial and Ceftin, Omnicef is a cephalosporin antibiotic.

Side effects of Xenleta and Ceftin, Omnicef that are similar include headache, diarrhea, nausea, and vomiting.

Side effects of Xenleta that are different from Ceftin, Omnicef include injection site reactions, elevated liver enzymes, low blood potassium, and insomnia.

Side effects of Ceftin, Omnicef that are different from Xenleta include dizziness, drowsiness, itching/swelling, rash, abdominal pain, stomach upset, gas, itching or rash, hives, cough, stuffy nose, stiff or tight muscles, muscle pain, joint pain or swelling, restlessness, irritability, hyperactivity, vaginal itching or discharge, unusual or unpleasant taste in the mouth, white patches or sores in the mouth, and diaper rash (in infants taking liquid cefuroxime).

Xenleta may interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors, alprazolam, diltiazem, verapamil, simvastatin, vardenafil, antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, and tricyclic antidepressants.

Ceftin, Omnicef may interact with vaccines (for example, typhoid vaccine) and probenecid.

Common side effects of Xenleta include:

• injection site reactions,
• elevated liver enzymes,
• nausea,
• low blood potassium,
• insomnia,
• headache,
• diarrhea,
• nausea, and
• vomiting

Common side effects of Ceftin, Omnicef include:

• diarrhea
• dizziness
• headache
• drowsiness
• itching/swelling
• rash
• nausea
• vomiting
• abdominal pain
• stomach upset
• gas
• headache
• itching or rash
• hives
• cough
• stuffy nose
• stiff or tight muscles
• muscle pain
• joint pain or swelling
• restlessness
• irritability
• hyperactivity
• vaginal itching or discharge
• unusual or unpleasant taste in the mouth
• white patches or sores in the mouth, and
• diaper rash (in infants taking liquid cefuroxime).

Tell your doctor if you experience serious side effects of Ceftin, Omnicef including watery or bloody diarrhea, fever, chills, body aches, flu symptoms, chest pain, fast or pounding heartbeats, unusual bleeding, blood in your urine or dark colored urine, seizure (convulsions), confusion, weakness, jaundice (yellowing of the skin or eyes), severe blistering/peeling/red skin rash, bruising, severe tingling, numbness, pain, muscle weakness, increased thirst, loss of appetite, swelling, weight gain, shortness of breath, painful or difficult urination, or urinating less than usual or not at all.

Xenleta (lefamulin) is a pleuromutilin antibacterial indicated for the treatment of adults with community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms.

Ceftin, Omnicef (cefuroxime) is a cephalosporin antibiotic. Ceftin, Omnicef is available as a generic drug and is prescribed to treat infections with susceptible bacteria including skin and middle ear infections, tonsillitis, throat infections, laryngitis, bronchitis, pneumonia, urinary tract infections, and gonorrhea.

Xenleta may interact with strong CYP3A4 inducers or P-gp inducers, strong CYP3A inhibitors or P-gp inhibitors, alprazolam, diltiazem, verapamil, simvastatin, vardenafil, antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, and tricyclic antidepressants. Tell your doctor all medications and supplements you use. Xenleta is not recommended for use during pregnancy; it may harm a fetus. Females of reproductive potential are advised to use effective contraception during treatment with Xenleta and for 2 days after the final dose. It is unknown if Xenleta passes into breast milk. Because of the potential for adverse reactions in nursing infants, breastfeeding is not recommended while using Xenleta. Women should pump and discard breast milk for the duration of treatment with Xenleta and for 2 days after the final dose.

Drug interactions with Ceftin, Omnicef include vaccines (for example, typhoid vaccine) and probenecid.

The recommended dosage of Xenleta is 150 mg every 12 hours by intravenous infusion over 60 minutes for 5 to 7 days or 600 mg orally every 12 hours for 5 days.

Ceftin, Omnicef oral dose range in adults is from 125mg to 500mg twice daily for 7-10 days and dosage in children is usually weight based.