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Zulresso vs. Trintellix

Are Zulresso and Trintellix the Same Thing?

Zulresso (brexanolone) Injection and Trintellix (vortioxetine) are antidepressants used to treat depression.

Zulresso is specifically used to treat postpartum depression (PPD) in adults. Zulresso is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the Zulresso REMS.

Zulresso and Trintellix are different types of antidepressants. Zulresso is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor positive modulator and Trintellix is a serotonin modulator.

Side effects of Zulresso and Trintellix that are similar include dry mouth.

Side effects of Zulresso that are different from Trintellix include drowsiness, sleepiness, loss of consciousness, flushing, and hot flushes.

Side effects of Trintellix that are different from Zulresso include nausea, diarrhea, dry mouth, constipation, vomiting, gas, dizziness, abnormal dreams, itching, and decreased sexual desire.

Both Zulresso and Trintellix may interact with other antidepressants.

Zulresso may also interact with CNS depressants (e.g., opioids, benzodiazepines).

Trintellix may also interact with monoamine oxidase inhibitors (MAOIs), triptans, buspirone, tramadol, tryptophan products, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, warfarin, quinidine, rifampicin, and seizure medications.

What Are Possible Side Effects of Zulresso?

Common side effects of Zulresso include:

  • nausea
  • diarrhea
  • dry mouth
  • constipation
  • vomiting
  • gas
  • dizziness
  • abnormal dreams
  • itching, and
  • decreased sexual desire

What Are Possible Side Effects of Trintellix?

Common side effects of Trintellix include:

  • nausea
  • diarrhea
  • dry mouth
  • constipation
  • vomiting
  • gas
  • dizziness
  • abnormal dreams
  • itching, and
  • decreased sexual desire

Antidepressants such as Trintellix increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Tell your doctor if you experience any thoughts of suicide while taking Trintellix.

What Is Zulresso?

Zulresso (vortioxetine) tablets are an antidepressant indicated for the treatment of major depressive disorder (MDD).

What Is Trintellix?

Trintellix (vortioxetine) tablets are an antidepressant indicated for the treatment of major depressive disorder (MDD).

What Drugs Interact With Zulresso?

Zulresso may interact with monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, buspirone, tramadol, tryptophan products, NSAIDs, aspirin, warfarin, bupropion, fluoxetine, paroxetine, quinidine, rifampicin, carbamazepine, and phenytoin. Tell your doctor all medications and supplements you use.

What Drugs Interact With Trintellix?

Trintellix may interact with monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, buspirone, tramadol, tryptophan products, NSAIDs, aspirin, warfarin, bupropion, fluoxetine, paroxetine, quinidine, rifampicin, carbamazepine, and phenytoin. Tell your doctor all medications and supplements you use.

How Should Zulresso Be Taken?

The recommended starting dose of Zulresso is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated.

How Should Trintellix Be Taken?

The recommended starting dose of Trintellix is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated.

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