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Trintellix Drug Description: Detailed Datasheet

Medically reviewed by Min Clinic Staff | Updated: January 2026
  • Generic Name: vortioxetine tablets
  • Brand Name: Trintellix

side effects drug center trintellix (vortioxetine tablets) drug

 

PROFESSIONAL

CONSUMER

SIDE EFFECTS

Drug Description

What is Trintellix and how is it used?

Trintellix is a prescription medicine used to treat the symptoms of major depressive disorder. Trintellix may be used alone or with other medications.

Trintellix belongs to a class of drugs called Antidepressants, Other.

It is not known if Trintellix is safe and effective in children.

What are the possible side effects of Trintellix?

Trintellix may cause serious side effects including:

  • agitation,
  • restlessness,
  • confusion,
  • rapid heart rate,
  • sweating or fever
  • nausea or vomiting
  • diarrhea
  • muscle stiffness or tightness
  • abnormal bleeding or bruising. TRINTELLIX may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a nonsteroidal anti-inflammatory drug (NSAID), or aspirin.
  • hypomania (manic episodes). Symptoms of manic episodes include:
    • greatly increased energy
    • racing thoughts
    • unusually grand ideas
    • reckless behavior
    • severe problems sleeping
    • talking more or faster than usual
    • excessive happiness or irritability
  • visual problems
    • eye pain
    • changes in vision
    • swelling or redness in or around the eye

    • Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

    • low levels of salt (sodium) in your blood. Symptoms of this may include: headache, difficulty concentrating, memory changes, confusion, weakness and unsteadiness on your feet. Symptoms of severe or sudden cases of low salt levels in your blood may include: hallucinations (seeing or hearing things that are not real), fainting, seizures and coma. If not treated, severe low sodium levels can cause death.

    Common side effects in people who take TRINTELLIX include:

    • nausea
    • constipation
    • vomiting

    These are not all the possible side effects of TRINTELLIX. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    How should I store TRINTELLIX?

    Store TRINTELLIX at room temperature between 59°F to 86°F (15°C to 30°C).

    Keep TRINTELLIX and all medicines out of the reach of children.

    General information about the safe and effective use of TRINTELLIX.

    Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use TRINTELLIX for a condition for which it was not prescribed. Do not give TRINTELLIX to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about TRINTELLIX that is written for healthcare professionals.

    What are the ingredients in TRINTELLIX?

    Active ingredient: vortioxetine hydrobromide

    Inactive ingredients: mannitol, microcrystalline cellulose, hydroxypropyl cellulose, sodium starch glycolate, magnesium stearate and film coating consisting of hypromellose, titanium dioxide, polyethylene glycol 400, iron oxide red (5 mg and 20 mg) and iron oxide yellow (10 mg)

    This Medication Guide has been approved by the U.S. Food and Drug Administration.