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Brintellix (Trintellix) vs. Zoloft

Are Brintellix (Trintellix) and Zoloft the Same Thing?

Brintellix (vortioxetine) and Zoloft (sertraline) are antidepressants used to treat major depressive disorder (MDD).

Zoloft is also used to treat obsessive-compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

The brand name Brintellix was changed to Trintellix in June 2016 because of confusion with the name of an antiplatelet drug called Brilinta (ticagrelor).

What Are Possible Side Effects of Brintellix (Trintellix)?

Common side effects of Brintellix (Trintellix) include:

What Are Possible Side Effects of Zoloft?

Common side effects of Zoloft include:

Tell your doctor if you have serious side effects of Zoloft including:

  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
  • agitation, hallucinations, fever, overactive reflexes, tremors;
  • nausea, vomiting, loss of appetite, feeling unsteady, loss of coordination;
  • trouble concentrating, memory problems, weakness, fainting, seizure, shallow breathing, or breathing that stops.

What Is Brintellix (Trintellix)?

Brintellix (vortioxetine) is an antidepressant used to treat major depressive disorder (MDD).

What Is Zoloft?

Zoloft (sertraline) is an SSRI (selective serotonin reuptake inhibitors) antidepressant prescribed for the treatment of depression, obsessive compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

 

What Drugs Interact With Brintellix (Trintellix)?

Brintellix may interact with monoamine oxidase inhibitors (MAOIs), SSRIs, SNRIs, triptans, buspirone, tramadol, tryptophan, bupropion, fluoxetine, paroxetine, quinidine, rifampicin, carbamazepine, or phenytoin. Tell your doctor all medications and supplements you use. Tell your doctor if you become pregnant or intend to become pregnant during therapy with Brintellix.

What Drugs Interact With Zoloft?

Zoloft may interact with cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, medicines for seizures or anxiety, other antidepressants, nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners, cimetidine, fentanyl, St. John's wort, tramadol, L-tryptophan, heart medications, or migraine headache medicines.

Zoloft may also interact with digoxin, linezolid, lithium, or valproate.

Do not take Zoloft if you:

  • take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid.
  • have taken an MAOI within 2 weeks of stopping Zoloft unless directed to do so by your healthcare provider.
  • have stopped taking an MAOI in the last 2 weeks unless directed to do so by your healthcare provider.
  • take any other medicines that contain sertraline (such as sertraline HCl or sertraline hydrochloride).
  • take the antipsychotic medicine pimozide (Orap®) because this can cause serious heart problems.
  • are allergic to sertraline or any of the ingredients in Zoloft. See the end of this Medication Guide for a complete list of ingredients in Zoloft.
  • take Antabuse® (disulfiram) (if you are taking the liquid form of Zoloft) due to the alcohol content.

If Zoloft is discontinued abruptly, withdrawal side effects may include abdominal cramps, flu-like symptoms, fatigue, and memory impairment.

 

How Should Brintellix (Trintellix) Be Taken?

The recommended starting dose of Brintellix is 10 mg taken orally once daily.

How Should Zoloft Be Taken?

Take Zoloft exactly as prescribed. Your healthcare provider may need to change the dose of Zoloft until it is the right dose for you.

Zoloft Tablets may be taken with or without food.

Zoloft Oral Solution may look cloudy or hazy after mixing, this is normal.

Zoloft Oral Solution must be diluted before use:

Do not mix Zoloft until you are ready to take it.

When diluting Zoloft Oral Solution, use only water, ginger ale, lemon/lime soda, lemonade, or orange juice.

The oral dropper contains latex. If you are sensitive or allergic to latex, ask your healthcare provider or pharmacist about the best way to measure your medicine.

If you miss a dose of Zoloft, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time.Do not take two doses of Zoloft at the same

time.

If you take too much Zoloft, call your healthcare provider or poison control center right away, or go to the nearest hospital emergency room right away.