Trintellix vs. Celexa

Trintellix (vortioxetine) and Celexa (citalopram hydrobromide) are selective serotonin reuptake inhibitor (SSRI) type antidepressants used to treat major depressive disorder (MDD).

Side effects of Trintellix and Celexa that are similar include nausea, diarrhea, dry mouth, constipation, dizziness, and decreased sexual desire.

Side effects of Trintellix that are different from Celexa include vomiting, gas, abnormal dreams, and itching.

Side effects of Celexa that are different from Trintellix include upset stomach, impotence, difficulty having an orgasm, drowsiness, tiredness, sleep problems (insomnia), increased sweating or urination, weight changes, and cold symptoms (such as stuffy nose, sneezing, sore throat, and cough).

Both Trintellix and Celexa may interact with other antidepressants, tramadol, L-tryptophan, nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners, anti-malaria medications, migraine headache medicines, and seizure medications.

Trintellix may also interact with monoamine oxidase inhibitors (MAOIs), buspirone, aspirin, bupropion, and rifampicin.

Celexa may also interact with alcohol, other drugs that make you sleepy or slow your breathing (such as sleeping pills, narcotics, muscle relaxers, or medicine for anxiety, depression, or seizures), lithium, St. John's wort, tacrolimus, arsenic trioxide, vandetanib, antibiotics, heart rhythm medications, HIV/AIDS medications, medicine to prevent or treat nausea and vomiting, medicines to treat psychiatric disorders, and stomach acid reducers.

Do not stop using Celexa suddenly, or you could have unpleasant withdrawal symptoms.

Common side effects of Trintellix include:

• nausea
• diarrhea
• dry mouth
• constipation
• vomiting
• gas
• dizziness
• abnormal dreams
• itching, and
• decreased sexual desire

Antidepressants such as Trintellix increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Tell your doctor if you experience any thoughts of suicide while taking Trintellix.

Common side effects of Celexa include:

• constipation,
• nausea,
• diarrhea,
• upset stomach,
• decreased sexual desire,
• impotence,
• difficulty having an orgasm,
• dizziness,
• drowsiness,
• tiredness,
• sleep problems (insomnia),
• dry mouth,
• increased sweating or urination,
• weight changes, and cold symptoms such as stuffy nose,
• sneezing, sore throat, or
• cough.

Trintellix (vortioxetine) tablets are an antidepressant indicated for the treatment of major depressive disorder (MDD).

Celexa is a prescription medicine used to treat depression. It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it. You should discuss all treatment choices with your healthcare provider. Celexa is also used to treat Major Depressive Disorder (MDD).

Talk to your healthcare provider if you do not think that your condition is getting better with Celexa treatment.

Trintellix may interact with monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, buspirone, tramadol, tryptophan products, NSAIDs, aspirin, warfarin, bupropion, fluoxetine, paroxetine, quinidine, rifampicin, carbamazepine, and phenytoin. Tell your doctor all medications and supplements you use.

Do not take Celexa if you:

• are allergic to citalopram hydrobromide or escitalopram oxalate or any of the ingredients in Celexa. See the end of this Medication Guide for a complete list of ingredients in Celexa.
• take a monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid.
• Do not take an MAOI within 2 weeks of stopping Celexa unless directed to do so by your physician.
• Do not start Celexa if you stopped taking an MAOI in the last 2 weeks unless directed to do so by your physician.
• People who take Celexa close in time to an MAOI may have serious or even life-threatening side effects. Get medical help right away if you have any of these symptoms:
• high fever
• uncontrolled muscle spasms
• stiff muscles
• rapid changes in heart rate or blood pressure
• confusion
• loss of consciousness (pass out)
• take the antipsychotic medicine pimozide (Orap®) because this can cause serious heart problems.
• have a heart problem including congenital long QT syndrome

Before starting Celexa, tell your healthcare provider if you are taking certain drugs such as:

• Medicines for heart problems
• Medicines that lower your potassium or magnesium levels in your body
• Cimetidine
• Triptans used to treat migraine headache
• Medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, amphetamines, or antipsychotics
• Tramadol
• Over-the-counter supplements such as tryptophan or St. John's Wort

Before starting Celexa, tell your healthcare provider if you:

• have liver problems
• have kidney problems
• have heart problems
• have or had seizures or convulsions
• have bipolar disorder or mania
• have low sodium levels in your blood
• have a history of a stroke
• have high blood pressure
• have or had bleeding problems
• are pregnant or plan to become pregnant. It is not known if Celexa will harm your unborn baby. Talk to your healthcare provider about the benefits and risks of treating depression during pregnancy
• are breast-feeding or plan to breastfeed. Some Celexa may pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking Celexa

Tell your healthcare provider about all the medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Celexa and some medicines may interact with each other, may not work as well, or may cause serious side effects.

Your healthcare provider or pharmacist can tell you if it is safe to take Celexa with your other medicines. Do not start or stop any medicine while taking Celexa without talking to your healthcare provider first.

The recommended starting dose of Trintellix is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated.

Take Celexa exactly as prescribed. Your healthcare provider may need to change the dose of Celexa until it is the right dose for you.

Celexa may be taken with or without food.

If you miss a dose of Celexa, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Celexa at the same time.

If you take too much Celexa, call your healthcare provider or poison control center right away, or get emergency treatment.