Trintellix vs. Irenka

Trintellix (vortioxetine) and Irenka (duloxetine capsule) are antidepressants used to treat major depressive disorder.

Irenka is also used to treat generalized anxiety disorder, diabetic peripheral neuropathy, and chronic musculoskeletal pain.

Trintellix and Irenka (duloxetine capsule) are different types of antidepressants. Irenka is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant and Trintellix is a serotonin modulator.

Side effects of Trintellix that are different from Irenka include vomiting, gas, abnormal dreams, itching, and decreased sexual desire.

Side effects of Irenka and Trintellix that are similar include nausea, dry mouth, constipation, dizziness, and diarrhea.

Side effects of Irenka that are different from Trintellix include headache, drowsiness, fatigue, insomnia, decreased appetite, increased sweating, and abdominal pain.

Both Trintellix and Irenka may interact with other antidepressants, monoamine oxidase inhibitors (MAOIs), nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, warfarin, triptans for migraine, tramadol, tryptophan, and buspirone.

Trintellix may also interact with quinidine, rifampicin, and seizure medications.

Irenka may also interact with alcohol, cimetidine, some antibiotics, aluminum- and magnesium-containing antacids, theophylline, caffeine, desipramine, fentanyl, lithium, and St. John's wort.

Common side effects of Trintellix include:

• nausea
• diarrhea
• dry mouth
• constipation
• vomiting
• gas
• dizziness
• abnormal dreams
• itching, and
• decreased sexual desire

Antidepressants such as Trintellix increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Tell your doctor if you experience any thoughts of suicide while taking Trintellix.

Common side effects of Irenka include:

• nausea,
• headache,
• dry mouth,
• drowsiness,
• fatigue,
• insomnia,
• constipation,
• dizziness,
• diarrhea,
• decreased appetite,
• increased sweating, and
• abdominal pain

Trintellix (vortioxetine) tablets are an antidepressant indicated for the treatment of major depressive disorder (MDD).

Irenka (duloxetine capsule) is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant used to treat major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathy, and chronic musculoskeletal pain.

Trintellix may interact with monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, buspirone, tramadol, tryptophan products, NSAIDs, aspirin, warfarin, bupropion, fluoxetine, paroxetine, quinidine, rifampicin, carbamazepine, and phenytoin. Tell your doctor all medications and supplements you use.

Irenka may interact with monoamine oxidase inhibitors (MAOIs), cimetidine, fluoroquinolone antibiotics, selective serotonin reuptake inhibitors (SSRIs), nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, warfarin, aluminum- and magnesium-containing antacids, theophylline, caffeine, desipramine, alcohol, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John's wort. Tell your doctor all medications and supplements you use.

The recommended starting dose of Trintellix is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated.

The dose of Irenka is 40 mg/day (given as 20 mg twice daily) to 60 mg/day (given either once daily or as 30 mg twice daily) for major depressive disorder, and 60 mg/day for generalized anxiety disorder, diabetic peripheral neuropathy, and chronic musculoskeletal pain.