Yuvafem vs. Premarin

Yuvafem (estradiol tablet) and Premarin (conjugated estrogens) are forms of the female hormone estrogen used to treat atrophic vaginitis due to menopause.

Premarin is also used to treat symptoms of menopause such as hot flashes. Premarin is also used to prevent osteoporosis in postmenopausal women, and replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Conjugated estrogens such as Premarin are sometimes used as part of cancer treatment in women and men.

Side effects of Yuvafem and Premarin that are similar include vaginal itching, headache, and abdominal pain/stomach upset or cramps.

Side effects of Yuvafem that are different from Premarin include back pain, diarrhea, vaginal yeast infection, and upper respiratory tract infection.

Side effects of Premarin that are different from Yuvafem include nausea, vomiting, bloating, breast tenderness or swelling, weight or appetite changes, freckles or darkening of facial skin, increased hair growth, loss of scalp hair, problems with contact lenses, vaginal discharge, changes in menstrual periods, decreased sex drive, nervousness, dizziness, and tired feeling.

Both Yuvafem and Premarin may interact with seizure medicines, barbiturates, rifampin, ketoconazole, and itraconazole.

Yuvafem may also interact with St. John's wort, erythromycin, clarithromycin, ritonavir, and grapefruit juice.

Premarin may also interact with blood thinners, thyroid medications, insulin or oral diabetes medicines, and antidepressants.

What Are Side Effects of Yuvafem?

Side effects of Yuvafem include:

• back pain,
• diarrhea,
• vaginal yeast infection,
• vaginal itching,
• headache,
• abdominal pain, and
• upper respiratory tract infection

Common side effects of Premarin Vaginal Cream include:

• nausea,
• vomiting,
• bloating,
• stomach cramps,
• breast pain/tenderness/swelling,
• headache,
• weight changes,
• changes in appetite,
• freckles or darkening of facial skin,
• increased hair growth,
• loss of scalp hair,
• problems with contact lenses,
• vaginal itching or discharge,
• changes in your menstrual periods,
• decreased sex drive,
• nervousness,
• dizziness, or
• tired feeling.

Yuvafem (estradiol tablet) is a form of the female hormone estrogen used to treat atrophic vaginitis due to menopause.

Premarin Vaginal Cream (conjugated estrogens) is a mixture of estrogen hormones, a female sex hormone produced by the ovaries, used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

Yuvafem may interact with other medicines such as:

• St. John's wort,
• phenobarbital,
• carbamazepine,
• rifampin,
• erythromycin,
• clarithromycin,
• ketoconazole,
• itraconazole,
• ritonavir, and
• grapefruit juice

Tell your doctor all medications and supplements you use.

Premarin Vaginal Cream may interact with blood thinners, thyroid medications, insulin or diabetes medicine taken by mouth, rifampin, ketoconazole or itraconazole, seizure medicines, barbiturates, or antidepressants. Tell your doctor all medications you are taking.

Yuvafem should be administered intravaginally using the supplied applicator: 1 insert daily for 2 weeks, followed by 1 insert twice weekly (for example, Tuesday and Friday). Generally, women should be started at the 10 mcg dosage strength.

Premarin Vaginal Cream is administered intravaginally in a cyclic regimen (daily for 21 days and then off for 7 days). The usual starting dosage strength is 0.5 g. Adjustments may be made based on individual response.