Trental vs. Eliquis

• Are Eliquis and Trental the Same Thing?
• What Are Possible Side Effects of Trental?
• What Are Possible Side Effects of Eliquis?
• What is Trental?
• What is Eliquis?
• What Drugs Interact with Trental?
• What Drugs Interact with Eliquis?
• How Should Trental Be Taken?
• How Should Eliquis Be Taken?

Trental (pentoxifylline) and Eliquis (apixaban) are used to treat vascular disease (disease related to veins and arteries).

Trental is used to improve blood flow. Improved blood flow helps reduce leg cramps and other symptoms of vascular disease (disease related to veins and arteries).

Eliquis reduces blood clotting and reduces the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

Trental and Eliquis belong to different drug classes. Trental is a hemorrheologic agent and Eliquis is an anticoagulant (blood thinner).

Side effects of Trental and Eliquis that are similar include nausea.

Side effects of Trental that are different from Eliquis include vomiting, upset stomach, bloating, belching, gas, diarrhea, dizziness, headache, blurred vision, and flushing (warmth, redness, or tingly feeling).

Side effects of Eliquis that are different from Trental include skin rash, allergic reactions, fainting, and anemia.

Both Trental and Eliquis may interact with blood thinners.

Trental may also interact with theophylline, aminophylline, dyphylline, and oxtriphylline. Tobacco may worsen your condition or decrease the beneficial effects of Trental by narrowing your blood vessels.

Eliquis may also interact with any other medicines to treat or prevent blood clots, antidepressants, and nonsteroidal anti-inflammatory drugs (NSAIDs) used long term.

Common side effects of Trental include:

• nausea,
• vomiting,
• gas,
• bloating,
• belching,
• upset stomach,
• diarrhea,
• dizziness,
• headache,
• blurred vision, or
• flushing (warmth, redness, or tingly feeling).

Tell your doctor if you have serious side effects of Trental including:

• chest pain,
• fast or irregular heartbeat,
• easy bruising or bleeding,
• feeling like you might pass out,
• red or pink urine,
• bloody or tarry stools, or
• coughing up blood or vomit.

Common side effects of Eliquis include:

• skin rash,
• allergic reactions,
• fainting, nausea, and
• anemia.

Tell your doctor if you have serious side effects of Eliquis including easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), bleeding from wounds or needle injections, any bleeding that will not stop; heavy menstrual periods; headache, dizziness, weakness, feeling like you might pass out; red, pink, or brown urine; black or bloody stools, coughing up blood or vomit that looks like coffee grounds; numbness, tingling, or muscle weakness (especially in your legs and feet); or loss of movement in any part of your body.

Trental (pentoxifylline) is a hemorrheologic agent (an agent that affects blood viscosity) used to improve blood flow. Improved blood flow helps reduce leg cramps and other symptoms of vascular disease (disease related to veins and arteries).

Eliquis (apixaban) is an anticoagulant (blood thinner) that reduces blood clotting and reduces the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

Trental may interact with blood thinners, theophylline, aminophylline, dyphylline, and oxtriphylline. Tobacco may worsen your condition or decrease the beneficial effects of Trental by narrowing your blood vessels. Talk to your doctor if you use tobacco. Tell your doctor all medications you use. During pregnancy, Trental should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breastfeeding.

Eliquis may interact with blood thinners and heparin, antibiotics, antidepressants, antifungals, antithrombotics, bone marrow stimulants, bosentan, conivaptan, cyclosporine, dextran, heart or blood pressure medications, hepatitis C medications, HIV/AIDS medications, imatinib, isoniazid, nefazodone, nonsteroidal anti-inflammatory drugs (NSAIDs), rifabutin, rifampin, rifapentine, salicylates (such as aspirin, Pepto-Bismol, and others), seizure medications, St. John's wort, thrombopoietic growth factors, or vasodilators.

The usual dosage of Trental in extended-release tablet form is one tablet (400 mg) three times a day with meals. It is recommended treatment is continued for at least 8 weeks.

The recommended dose of Eliquis for most patients is 5 mg taken orally twice daily.

The recommended dose of Eliquis is 2.5 mg twice daily in patients with at least two of the following characteristics:

• age ≥ 80 years
• body weight ≤ 60 kg
• serum creatinine ≥ 1.5 mg/dL