Sporanox vs. Nystatin

• Are Nystatin and Sporanox the Same Thing?
• What Are Possible Side Effects of Sporanox?
• What Are Possible Side Effects of Nystatin?
• What Is Sporanox?
• What Is Nystatin?
• What Drugs Interact with Sporanox?
• What Drugs Interact with Nystatin?
• How Should Sporanox Be Taken?
• How Should Nystatin Be Taken?

Sporanox (itraconazole) and nystatin are antifungal medications used to treat infections caused by fungus, which can invade any part of the body including the lungs, mouth or throat, toenails, or fingernails.

Sporanox is an oral medication and nystatin is a topical (for the skin) cream or powder or an oral rinse.

Side effects of Sporanox and nystatin that are similar include nausea, vomiting, diarrhea, stomach upset, skin rash, and muscle pain.

Side effects of Sporanox that are different from nystatin include constipation, bloating, gas, headache, dizziness, unpleasant taste in your mouth, itching, joint pain, muscle weakness, and runny nose or other cold symptoms.

Side effects of nystatin that are different from Sporanox include skin reactions from the cream (irritation, itching, or redness), mouth irritation (oral rinse), hives, allergic reaction, slow heart rate, bronchospasm, and facial swelling.

Sporanox may interact with blood thinners, cancer medications, cholesterol medications, cyclosporine, diabetes medications taken by mouth, antibiotics, antifungals, antidepressants, barbiturates, heart or blood pressure medications, HIV/AIDS medicines, sedatives, seizure medications, digoxin, disopyramide, fentanyl, isoniazid, rifabutin, rifampin, sirolimus, or tacrolimus.

Nystatin may interact with other drugs.

Common side effects of Sporanox include:

• nausea,
• vomiting,
• diarrhea,
• constipation,
• bloating,
• gas,
• headache,
• dizziness,
• stomach upset,
• unpleasant taste in your mouth,
• itching,
• skin rash,
• joint pain,
• muscle pain or weakness, or
• runny nose or other cold symptoms.

Tell your doctor if you have unlikely but serious side effects of Sporanox including:

• signs of infection (e.g., fever, persistent sore throat),
• trouble breathing,
• unusual tiredness,
• swelling ankles or feet,
• burning/painful/frequent urination,
• decreased sexual interest or ability,
• hair loss,
• muscle cramps,
• weakness,
• fast/irregular heartbeat,
• mental/mood changes (e.g., depression),
• enlarged breasts in men,
• ringing in the ears, or
• temporary or permanent hearing loss.

Common side effects of Nystatin include:

• skin irritation or redness,
• nausea,
• stomach upset,
• vomiting, or
• diarrhea

• skin irritation or redness,
• nausea,
• stomach upset,
• vomiting, or
• diarrhea

Sporanox (itraconazole) is an antifungal agent used to treat infections caused by fungus, which can invade any part of the body including the lungs, mouth or throat, toenails, or fingernails. Sporanox is available in generic form.

Nystatin is a topical (for the skin) antifungal used to treat fungal skin infections. Nystatin is available in generic form.

Many drugs may interact with Sporanox, including blood thinners, cancer medications, cholesterol medications, cyclosporine, diabetes medication taken by mouth, antibiotics, antifungal medications, antidepressants, barbiturates, heart or blood pressure medications, HIV/AIDS medicine, sedatives, seizure medications, digoxin, disopyramide, fentanyl, isoniazid, rifabutin, rifampin, sirolimus, or tacrolimus. Tell your doctor all medications you are taking. During pregnancy, Sporanox should be used only when prescribed. It may harm a fetus. Discuss the risks with your doctor.

There may be other drugs that can interact with Nystatin. Tell your healthcare provider about all your prescription and over-the-counter medications and supplements you use. Do not start a new medication without telling your healthcare provider. Nystatin should be used only if prescribed during pregnancy. It is not known whether this drug passes into breast milk.

Nystatin may also interact with alfentanil, fentanyl, clopidogrel, cyclophosphamide, cyclosporine, methadone, pimozide, prednisone, saquinavir, zidovudine, sirolimus, tacrolimus, theophylline, voriconazole, antidepressants, cancer medicines, cholesterol lowering medicines, heart or blood pressure medications, nonsteroidal anti-inflammatory drugs (NSAIDs), oral diabetes medications, rifabutin, rifampin, or sedatives.

Dosage of Sporanox depends upon the condition for which it is being used to treat.

The adult and pediatric dose of Nystatin cream is to apply liberally to affected areas twice daily or as indicated until healing is complete. The adult and pediatric dose of Nystatin powder for candidal lesions is to apply two or three times daily until healing is complete. For fungal infection of the feet caused by Candida species, the powder should be dusted on the feet and in all foot wear.