Neurontin vs. Cymbalta

• Are Neurontin and Cymbalta the Same Thing?
• What Are Possible Side Effects of Neurontin? (Side effects)
• What Are Possible Side Effects of Cymbalta? (Side effects)
• What is Neurontin? (Uses)
• What is Cymbalta? (Uses)
• What Drugs Interact with Neurontin? (Interactions)
• What Drugs Interact with Cymbalta? (Interactions)
• How Should Neurontin Be Taken? (Dosage)
• How Should Cymbalta Be Taken? (Dosage)

Neurontin (gabapentin) and Cymbalta (duloxetine) are both used to treat nerve pain.

Common side effects of Neurontin include:

• dizziness,
• drowsiness,
• unsteadiness,
• memory loss,
• lack of coordination,
• difficulty speaking,
• viral infections,
• tremors,
• double vision,
• fever,
• unusual eye movements, and
• jerky movements.

Common side effects of Cymbalta include:

• nausea,
• dry mouth,
• constipation,
• diarrhea,
• fatigue,
• tired feeling,
• drowsiness,
• difficulty sleeping,
• loss of appetite, and
• dizziness.

Neurontin is a prescription medicine used to treat:

• Pain from damaged nerves (postherpetic pain) that follows healing of shingles (a painful rash that comes after a herpes zoster infection) in adults.
• Partial seizures when taken together with other medicines in adults and children 3 years of age and older with seizures.

Cymbalta is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD). Cymbalta belongs to a class of medicines known as SNRIs (or serotonin-norepinephrine reuptake inhibitors).

Cymbalta is also used to treat or manage:

• Generalized Anxiety Disorder (GAD)
• Diabetic Peripheral Neuropathic Pain (DPNP)
• Fibromyalgia (FM)
• Chronic Musculoskeletal Pain

Do Not take Neurontin if you are allergic to gabapentin or any of the other ingredients in Neurontin. See the end of this Medication Guide for a complete list of ingredients in Neurontin.

Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking Neurontin without first talking with your healthcare provider. Taking Neurontin with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse. Do not drive, operate heavy machinery, or do other dangerous activities until you know how Neurontin affects you. Neurontin can slow your thinking and motor skills.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking Neurontin with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist when you get a new medicine.

Do Not take Cymbalta if you:

• take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid or intravenous methylene blue.
• Do not take an MAOI within 5 days of stopping Cymbalta unless directed to do so by your healthcare provider.
• Do not start Cymbalta if you stopped taking an MAOI in the last 14 days unless directed to do so by your healthcare provider.

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Cymbalta and some medicines may interact with each other, may not work as well, or may cause serious side effects.

Especially tell your healthcare provider if you take:

• triptans used to treat migraine headache
• medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, buspirone, SSRIs, SNRIs or MAOIs
• tramadol and fentanyl
• amphetamines
• cimetidine
• the antibiotics ciprofloxacin, enoxacin
• medicine to treat irregular heart rate (like propafenone, flecainide, quinidine)
• theophylline
• the blood thinner warfarin (Coumadin, Jantoven)
• non-steroidal anti-inflammatory drug (NSAID) (like ibuprofen, naproxen or aspirin).
• over-the-counter supplements such as tryptophan or St. John's Wort
• thioridazine (Mellaril). Mellaril together with Cymbalta can cause serious heart rhythm problems or sudden death.

Ask your healthcare provider for a list of these medicines if you are not sure.

Do not take Cymbalta with any other medicine that contain duloxetine.

Take Neurontin exactly as prescribed. Your healthcare provider will tell you how much Neurontin to take.

Do not change your dose of Neurontin without talking to your healthcare provider.

If you take Neurontin tablets and break a tablet in half, the unused half of the tablet should be taken at your next scheduled dose. Half tablets not used within 28 days of breaking should be thrown away. Take Neurontin capsules with water.

Neurontin tablets can be taken with or without food. If you take an antacid containing aluminum and magnesium, such as Maalox®, Mylanta®, Gelusil®, Gaviscon®, or Di-Gel®, you should wait at least 2 hours before taking your next dose of Neurontin.

If you take too much Neurontin, call your healthcare provider or your local Poison Control Center right away at 1-800-222-1222.

Take Cymbalta exactly as your healthcare provider tells you to take it. Your healthcare provider may need to change the dose of Cymbalta until it is the right dose for you.

Swallow Cymbalta whole. Do not chew or crush Cymbalta.

Do not open the capsule and sprinkle on food or mix with liquids. Opening the capsule may affect how well Cymbalta works.

Cymbalta may be taken with or without food.

If you miss a dose of Cymbalta, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Cymbalta at the same time.

If you take too much Cymbalta, call your healthcare provider or poison control center at 1-800-222-1222 right away, or get emergency treatment.

When switching from another antidepressant to Cymbalta your healthcare provider