Latuda vs. Rexulti

Latuda (lurasidone hydrochloride) and Rexulti (brexpiprazole) are atypical antipsychotics used to treat schizophrenia.

Rexulti is also used as adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD).

Side effects of Latuda and Rexulti that are similar include drowsiness, dizziness, shaking (tremors), weight gain, restlessness, or agitation.

Side effects of Latuda that are different from Rexulti include nausea, diarrhea, stomach pain, loss of appetite, muscle stiffness, mask-like facial expression, inability to keep still, blurred vision, breast swelling or discharge, missed menstrual periods, decreased sex drive, impotence, or difficulty having an orgasm.

Side effects of Rexulti that are different from Latuda include distress, constipation, fatigue, runny or stuffy nose, increased appetite, headache, or anxiety. Children, teenagers, and young adults may have suicidal thoughts while taking Rexulti.

Latuda may interact with diltiazem, azole antifungals, HIV drugs, antibiotics, rifamycins, antidepressants, or other products that cause dizziness or drowsiness, including alcohol, antihistamines, drugs for sleep or anxiety, muscle relaxants, and narcotics.

Rexulti may interact with strong/moderate CYP2D6 or CYP3A4 inhibitors or strong CYP3A4 inducers.

Side effects of Latuda include:

• drowsiness,
• dizziness,
• nausea,
• diarrhea,
• stomach pain,
• loss of appetite,
• shaking,
• muscle stiffness,
• weight gain,
• mask-like facial expression,
• inability to keep still,
• restlessness,
• agitation,
• blurred vision,
• breast swelling or discharge,
• missed menstrual periods,
• decreased sex drive,
• impotence, or
• difficulty having an orgasm.

Tell your doctor right if you experience serious side effects of Latuda including:

• drooling,
• trouble swallowing,
• fainting,
• signs of infection (such as persistent cough, fever)
• fast or uneven or pounding heartbeats;
• agitation, hostility, confusion, thoughts about hurting yourself,
• seizures (convulsions),
• fever, chills, body aches, flu symptoms,
• sores in your mouth and throat,
• high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss),
• very stiff (rigid) muscles, high fever, sweating, confusion, tremors, feeling like you might pass out, or
• twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.

Common side effects of Rexulti include:

• weight gain,
• agitation,
• distress,
• restlessness,
• constipation,
• fatigue,
• runny or stuffy nose,
• increased appetite,
• headache,
• drowsiness,
• tremor,
• dizziness, and
• anxiety.
• Children, teenagers, and young adults may have suicidal thoughts while taking Rexulti. Tell your doctor if this occurs.

Latuda (lurasidone hydrochloride) is an atypical antipsychotic used to treat schizophrenia.

Rexulti (brexpiprazole) is an atypical antipsychotic indicated for use as an adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD) and for treatment of schizophrenia.

Latuda may interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), antibiotics, antifungal medications, or medications to treat HIV or AIDS.

Latuda may also interact with diltiazem or rifamycins.

Rexulti may interact with strong/moderate CYP2D6 or CYP3A4 inhibitors or strong CYP3A4 inducers. Tell your doctor all medications and supplements you use. The effects of Rexulti on a fetus are unknown. Neonates whose mothers are exposed to antipsychotic drugs, like Rexulti, during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Rexulti during pregnancy. It is unknown if Rexulti passes into breast milk or if it would affect a nursing infant. Consult your doctor before breastfeeding.

The recommended starting dose of Latuda is 40 mg once dxily, and it has been shown to be effective in a dose range of 40 mg/day to 160 mg/day.

The recommended starting dosage for Rexulti as adjunctive treatment for MDD is 0.5 mg or 1 mg once daily, taken orally. The recommended target Rexulti dosage to treat schizophrenia is 2 mg to 4 mg once daily.