Krystexxa vs. Gloperba

• Are Krystexxa and Gloperba the Same Thing?
• What Are Possible Side Effects of Krystexxa?
• What Are Possible Side Effects of Gloperba?
• What Is Krystexxa?
• What Is Gloperba?
• What Drugs Interact with Krystexxa?
• What Drugs Interact with Gloperba?
• How Should Krystexxa Be Taken?
• How Should Gloperba Be Taken?

Krystexxa (pegloticase) Injection and Gloperba (colchicine) Oral Solution are used to treat gout.

Krystexxa is usually given after other gout medications have been tried without successful treatment of symptoms.

Krystexxa and Gloperba belong to different drug classes. Krystexxa is an enzyme and Gloperba is an anti-gout agent.

Side effects of Krystexxa and Gloperba that are similar include nausea and vomiting.

Side effects of Krystexxa that are different from Gloperba include sore throat, runny or stuffy nose, new gout flares, constipation, easy bruising, and hives.

Side effects of Gloperba that are different from Krystexxa include gastrointestinal symptoms, including diarrhea and abdominal pain.

Krystexxa may interact with other drugs.

Gloperba may interact with grapefruit juice, erythromycin, verapamil, cyclosporine, clarithromycin, ketoconazole, HMG-CoA reductase inhibitors (statins), and fibrates.

Common side effects of Krystexxa include:

• nausea
• vomiting
• sore throat
• runny or stuffy nose
• new gout flares
• constipation
• easy bruising, and
• hives

Tell your doctor if you have serious side effects of Krystexxa including

• chest pain, or
• flushing (warmth, redness, or tingly feeling)

Common side effects of Gloperba include:

• gastrointestinal symptoms,
• including diarrhea,
• nausea,
• vomiting, and
• abdominal pain

Krystexxa (pegloticase) Injection for Intravenous Infusion is an enzyme that metabolizes uric acid into a harmless chemical that is eliminated from the body in urine and is used to treat chronic gout. Krystexxa is usually given after other gout medications have been tried without successful treatment of symptoms.

Gloperba (colchicine) Oral Solution is an anti-gout agent indicated for prevention of gout flares in adults.

Krystexxa may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Krystexxa should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Gloperba may interact with grapefruit juice, erythromycin, verapamil, cyclosporine, clarithromycin, ketoconazole, HMG-CoA reductase inhibitors (statins), and fibrates. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Gloperba; it is not expected to harm a fetus at normal doses. Gloperba may very rarely cause infertility in males. Gloperba passes into breast milk. Consult your doctor before breastfeeding.

The recommended dose and regimen of Krystexxa for adult patients is 8 mg (uricase protein) given as an intravenous infusion every two weeks.

The dose of Gloperba is 0.6 mg (5 mL) once or twice daily.