Duexis vs. Vimovo

• Are Vimovo and Duexis the Same Thing?
• What Are Possible Side Effects of Duexis?
• What Are Possible Side Effects of Vimovo?
• What is Duexis?
• What is Vimovo?
• What Drugs Interact with Duexis?
• What Drugs Interact with Vimovo?
• How Should Duexis Be Taken?
• How Should Vimovo Be Taken?

Duexis (ibuprofen and famotidine) and Vimovo (naproxen and esomeprazole magnesium) are combination drugs used to treat signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing gastrointestinal ulcers.

Both Duexis and Vimovo contain a nonsteroidal anti-inflammatory drug (NSAID). The difference is Duexis also contains a histamine H2-receptor antagonist while Vimovo contains a proton pump inhibitor (PPI).

Common side effects of Duexis include:

• stomach pain,
• upset stomach,
• constipation,
• diarrhea,
• bloating,
• gas,
• heartburn,
• nausea,
• vomiting,
• dizziness,
• headache,
• throat irritation,
• blurred vision,
• changes in color vision, or
• back pain.

Duexis can cause serious or fatal side effects including:

• heart attack,
• stroke,
• gastrointestinal bleeding or ulceration, and
• perforation of the stomach or intestines.

Common side effects of Vimovo include:

• upset stomach,
• stomach pain,
• heartburn,
• nausea,
• gas,
• diarrhea,
• constipation,
• drowsiness, or
• dizziness.

Tell your doctor if you have serious side effects of Vimovo including:

• easy bruising or bleeding,
• lightheadedness,
• fainting,
• signs of a lung infection (such as fever, cough, trouble breathing),
• difficult or painful swallowing,
• swelling of the hands or feet,
• sudden or unexplained weight gain,
• symptoms of a low magnesium blood level (such as unusually fast/slow/irregular heartbeat, or persistent muscle spasms, seizures).

Duexis (ibuprofen and famotidine) is a combination of a nonsteroidal anti-inflammatory drug (NSAID) and a histamine H2-receptor antagonist used to treat signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing upper gastrointestinal ulcers.

Vimovo (naproxen and esomeprazole magnesium) is a combination of a nonsteroidal anti-inflammatory drug (NSAID) and a proton pump inhibitor (PPI) used to treat signs and symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis when there is a high risk for stomach bleeding/ulcer.

Duexis may interact with ACE-inhibitors. Duexis contains ibuprofen and may interact with anticoagulant medication such as Warfarin (Coumadin). Tell your doctor all medications you use. Duexis should not be given to women in late stages of pregnancy. There is potential for adverse reactions in nursing infants; consult your doctor before breastfeeding.

Vimovo may interact with amphetamines, oral bisphosphonates, blood thinners, anti-platelet drugs, SSRI/SNRI antidepressants, clopidogrel, corticosteroids, HIV drugs, lithium, probenecid, digoxin, azole antifungals, iron supplements, other products containing naproxen, other proton pump inhibitors. Check medicine labels as many contain pain relievers/fever reducers similar to Vimovo and may increase the risk of side effects if taken together. Tell your doctor all medications and supplements you are taking.

Duexis is dosed as 800 mg/26.6 mg tablets, taken orally, three times per day.

The dosage of Vimovo is one tablet twice daily, 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole.