Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Histamine
Medically reviewed by Min Clinic Staff | Updated: January 2026
Histamine: A substance that plays a major role in many allergic reactions, dilating blood vessels and making the vessel walls abnormally permeable. Histamine is part of the body's natural allergic response to substances such as pollens. Antihistamines work by preventing the release of histamine from certain cells (mast cells) thereby blocking the allergic reaction.